The Correlation Between Blood Glucose Level and Lipid Profile in Hypothyroid Diabetic Patients in Baghdad

Abstract

The objective of this study was to investigate the effects of thyroid hormones disorders on serum lipid profile among the hypothyroidism diabetic patients. For this purpose blood samples were collected randomly from (40) subjects with hypothyroidism (TSH> 5 m IU/L, T4 < 50 n mol/L) (male and female) from the endocrine center of Al-Yarmook teaching hospital in the age range of (30- 65) years. Included (21) diabetic patients who had thyroid dysfunction (hypothyroidism) according to clinical examinations and laboratory results, (were chosen as case group) and the remaining (19) subjects were consider as control group.
The following variables were measured: Fasting serum glucose, thyroid hormones (T3, T4 and TSH) and lipid profiles (total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), Very Low density lipoprotein VLDL
and triglycerides (TG)).
The statistical analysis of results of this study revealed a significant correlation between fasting serum glucose (FSG) with severity of thyroid hormones disorders levels (T3, T4 and TSH), beside significantly increased serum total cholesterol (include HDL, LDL and VLDL) and triglyceride (P. value < 0.05) with hyperglycemia.
We conclude that hyperglycemia is associated with significant changes in lipid profile and thyroid hormones level in hypothyroid-diabetic patient as compared with non diabetic control group with negative correlations