Cytotoxicity–Associated gene (CagA) Producing Helicobacter pylori Increased Risk of Developing Colorectal Carcinoma in Iraqi Patients.

Wasan Abdulilah Bakir; Noor Hashim Ismail; Ayser Hameed Latif; Dina Wael Abd; Zena Zaki Saied

doi:10.32947/ajps.v14i1.139

Cytotoxicity–Associated gene (CagA) Producing Helicobacter pylori Increased Risk of Developing Colorectal Carcinoma in Iraqi Patients.

Authors

Wasan Abdulilah Bakir Iraqi centre for cancer andmedical genetic research, Al- Mustansiryiah University, Baghdad, Iraq.
Noor Hashim Ismail Iraqi centre for cancer andmedical genetic research, Al- Mustansiryiah University, Baghdad, Iraq.
Ayser Hameed Latif **Department of pathology/College of medicine, Al-Mustansiriyah University, Baghdad, Iraq.
Dina Wael Abd Iraqi centre for cancer andmedical genetic research, Al- Mustansiryiah University, Baghdad, Iraq.
Zena Zaki Saied Iraqi centre for cancer andmedical genetic research, Al- Mustansiryiah University, Baghdad, Iraq.

DOI:

https://doi.org/10.32947/ajps.v14i1.139

Keywords:

H. pylori, CagA, colorectal cancer

Abstract

Infection with Helicobacter pylori, particularly with strains positive for cytotoxicity–
associated gene (CagA) gene, increases the risk of gastric adenocarcinoma and it may be
associated with carcinogenesis in extra gastric target organ. The aim of this study to explore
the possible association between CagA positive H. pylori and colorectal carcinoma and
determine the association with clinico-pathological features.
Paraffin embedded tumor specimens from (49) patients with colorectal adenocarcinoma and (30) healthy control were assessed by in situ hybridization for the expression of H. pylori CagA mRNA.
Statistical analysis of H. pylori CagA positive expression revealed highly significant difference in colorectal carcinoma patients than in control group. There was no relationship between H. pylori CagA positive expression and range of clinicopathological features.
Among patients infected with H. pylori CagA positive is associated with increased risk for colonic cancer.

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Published

2014-06-01

How to Cite

Bakir, W. A., Ismail, N. H., Latif, A. H., Abd, D. W., & Saied, Z. Z. (2014). Cytotoxicity–Associated gene (CagA) Producing Helicobacter pylori Increased Risk of Developing Colorectal Carcinoma in Iraqi Patients. Al Mustansiriyah Journal of Pharmaceutical Sciences, 14(1), 143–149. https://doi.org/10.32947/ajps.v14i1.139

Issue

Vol. 14 No. 1 (2014): volume 14, Issue 1. 2014

Section

Articles

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