Effect of Tamsulosin on Biomarkers after Ureteral Stones Lithotripsy

Abstract

Since the aurora of civilization, urolithiasis has plagued humans. Defective drainage due to urinary tract obstruction at the narrowest part (ureterovesical junction, ureteropelvic junction, and near the pelvic brim) via stones will eventually cause the agonizing renal colic pain.  Therapeutic managements of urolithiasis to relief acute colic pain are the primary objective. Non-steroidal anti-inflammatory drugs are the most commonly used drugs as suggested by many studies. It is very important to consider side effects of the drugs used in the treatment of colic pain.

 In order to preserve renal function and to relief obstruction, medical expulsion therapy are used for ureteral calculi as a conservative management. These medications will aid the passage ureteral calculi, an area that currently seems to be a field for continuous investigation.The Aim of this Study is to compare renal biomarkers before and after Lithotripsy and to evaluate the effect of Tamsulosin on these biomarkers in patients with ureteral stones.

  We concluded that, there were significant differences in the clinical outcomes obtained after using tamsulosin for 14 days in patients with ureteral stones who underwent lithotripsy compared with those patients who were not used tamsulosin; the levels of KIM-1, andserum urea were decreased significantly (p value <0.05) while the levels of ALP and serum sodium show an improvement when compared to patients who were not used tamsulosin but it's results were statistically not significant