Respiratory Distress and the Bacteria Causing Infection in the Neonates

Authors

  • Neihaya Heikmat Zaki Department of Biology, College of Science, University of Al- Mustansiriya

DOI:

https://doi.org/10.32947/ajps.v11i1.248

Keywords:

Respiratory Distress, Streptococcus agalactiae, E.coli, Neonates Staphylococcus aureus

Abstract

An analysis of 64 samples of (blood, vagina, anaus) from pregnant mothers and their neonates, only 58 samples showed these types of bacteria Streptococcus agalactiae(GBS), Staphylococcus aureus and Escherichia coli, distributed as: 16 blood isolates from mothers and 25 from neonates, while 13 vaginal isolates from mothers and 4 anal isolates from neonates. Bacterial components (phospholipids-PL) purified by High Performance Liquid Chromatography (HPLC), and identified as Cardiolipin (CL) with retention time (10.76 min.), Phosphatidylserine (PS) (8.1min.), and Phosphatidyl ethanolamine (PE) (5.9 min.) compared with standard PL. GBS isolates produced more extracellular phospholipids than other types in this
study.

The three types of bacteria differed in their levels of virulence when injected intratracheally in to a neonatal rabbit model to determine whether they induced pulmonary hypertension in it. After 8 days the rates of surviving neonatal rabbits were 2/15 (13.33%) to GBS, 5/15 to E.coli (33.33%), and 7/15 (46.66%) to S.aureus. The recognition that bacterial phospholipids may cause respiratory distress in newborns with these kinds of bacteria opens new avenues for therapeutic intervention.

Downloads

Published

2012-06-01

How to Cite

Zaki, N. H. (2012). Respiratory Distress and the Bacteria Causing Infection in the Neonates. Al Mustansiriyah Journal of Pharmaceutical Sciences, 11(1), 139–149. https://doi.org/10.32947/ajps.v11i1.248