Synthesis and antimicrobial evaluation of Histidine Cinnamaldehyde Schiff base containing structural feature of 1, 3, 4-thiadiazole heterocyclic moiety

Doaa Mahmood Ibrahim; Karima Fadhil Ali; Mayada Hadi Abd_alwahab

doi:10.32947/ajps.v20i1.681

Synthesis and antimicrobial evaluation of Histidine Cinnamaldehyde Schiff base containing structural feature of 1, 3, 4-thiadiazole heterocyclic moiety

Authors

Doaa Mahmood Ibrahim Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad-Iraq
Karima Fadhil Ali Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad-Iraq
Mayada Hadi Abd_alwahab Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad-Iraq

DOI:

https://doi.org/10.32947/ajps.v20i1.681

Keywords:

Histidine, Schiff bases, 1, 3, 4-thiadiazole, Antimicrobial activity

Abstract

Reaction of aqueous solution of amino acid Histidine with ethanolic solution Cinnamaldehyde to synthesize the desired Schiff base. Then, the derivative of 1, 3, 4-thiadiazole ring have been synthesized by reaction of the imine derivative with Thiosemicarbazide in presence of POCL_3.

The entire intermediate and final compound characterized and identified by elemental microanalysis as melting point, FT-IR spectra, 1H-NMR spectroscopy. Agar Well Diffusion method evaluated the antimicrobial activity on gram positive bacteria such as Staphylococcus aureus and Streptococcus pneumonia and gram-negative bacteria such as E coli & Acinetobacter species and also antifungal activity had been studied on one type of fungi (candida albicans).

Published

2020-06-01

How to Cite

Ibrahim, D. M., Ali, K. F., & Abd_alwahab, M. H. (2020). Synthesis and antimicrobial evaluation of Histidine Cinnamaldehyde Schiff base containing structural feature of 1, 3, 4-thiadiazole heterocyclic moiety. Al Mustansiriyah Journal of Pharmaceutical Sciences, 20(1), 1–12. https://doi.org/10.32947/ajps.v20i1.681

Issue

Vol. 20 No. 1 (2020): volume20,Issue1.2020

Section

Articles

License

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