The Impact of Vitamin D on The Development of Multiple Sclerosis (Review article)

Authors

  • Aseel Ghassan Daoud Clinical laboratory science /College of Pharmacy/ Mustansiriyah University/ Iraq.
  • Huda Jaber Waheed Clinical laboratory science /College of Pharmacy/ Mustansiriyah University/ Iraq
  • Mayssaa Essam Abdala Clinical laboratory science /College of Pharmacy/ Mustansiriyah University/ Iraq.

DOI:

https://doi.org/10.32947/ajps.v21i3.792

Abstract

Multiple Sclerosis is a harmful disease causes severe and painful symptoms. In the recent period, researchers have tended to study the effect of vitamin D deficiency on general health. Several studies have reported that there is a relation between vitamin D levels and MS disease progression. Epidemiological testimony

and reports have recorded that there are an association between the decrement in plasma vitamin D levels and the incidence of MS also with the disease development; and it has seen that when take vitamin D as supplement may protect the MS patients against disease development. Despite clear evidence of the correlation between disease progression and vitamin D deficiency but the mechanism yet unclear.

References

Mark Rametta and Anthony T. Reder. Vitamin D and Multiple Sclerosis: A Comprehensive Review. Neurol Ther. 2018 Jun; 7(1): 59–85. DOI: https://doi.org/10.1007/s40120-017-0086-4

- Armon-Omer A, Waldman C, Simaan N, Neuman H, Tamir S, Shahien R. New Insights on the Nutrition Status and Antioxidant Capacity in Multiple Sclerosis Patients. Nutrients. 2019 Feb; 11(2): 427. DOI: https://doi.org/10.3390/nu11020427

- Pierrot-Deseilligny C, Souberbielle JC. Vitamin D and multiple sclerosis: An update. Mult Scler Relat Disord. 2017 May;(14):35-45. DOI: https://doi.org/10.1016/j.msard.2017.03.014

- Munger K, Åivo J, Hongell K, Soilu-Hänninen M, Surcel H, Ascherio A. Vitamin D status during pregnancy and risk of multiple sclerosis in offspring of women in the Finnish maternity cohort. JAMA Neurol. 2016;73(5):515. DOI: https://doi.org/10.1001/jamaneurol.2015.4800

- Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011; 96:53–58. DOI: https://doi.org/10.1210/jc.2010-2704

- Behrens JR, Rasche L, Gieß RM, Pfuhl C, Wakonig K, Freitag E, et al. Low 25-hydroxyvitamin D, but not the bioavailable fraction of 25-hydroxyvitamin D, is a risk factor for multiple sclerosis. Eur J Neurol. 2016; 23:62–67. DOI: https://doi.org/10.1111/ene.12788

- Fullard ME, Xie SX, Marek K, Stern M, Jennings D, Siderowf A, et al. Vitamin D in the parkinson associated risk syndrome (PARS) study. Mov Disord. 2017; 32:1636–40. DOI: https://doi.org/10.1002/mds.27127

- Ascherio A, Munger K, Simon K. Vitamin D and multiple sclerosis. Lancet Neurol. 2010;9(6):599–612. DOI: https://doi.org/10.1016/S1474-4422(10)70086-7

- Health Quality Ontario. Clinical Utility of Vitamin D Testing: An Evidence-Based Analysis. 2010 p. 1-93.

- Meamar R, Shaabani P, Tabibian SR, Ghazvini MR, Feizi A. The effects of uric acid, serum vitamin D3, and their interaction on Parkinson’s disease severity. Parkinsons Dis. 2015; 2015:463–83. DOI: https://doi.org/10.1155/2015/463483

- Wang L, Evatt ML, Maldonado LG, Perry WR, Ritchie JC, Beecham GW, et al. Vitamin D from different sources is inversely associated with Parkinson disease. Mov Disord. 2015; 30:560–66. DOI: https://doi.org/10.1002/mds.26117

- Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, et al. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 2013; 81:1531–37. DOI: https://doi.org/10.1212/WNL.0b013e3182a95818

- Moghaddasi M, Mamarabadi M, Aghaii M. Serum 25-hydroxyvitamin D3 concentration in Iranian patients with Parkinson’s disease. Iran J Neurol. 2013; 12:56–59.

- Chitsaz A, Maracy M, Basiri K, Boroujeni MI, Tanhaei AP, Rahimi M, et al. 25-hydroxyvitamin d and severity of Parkinson’s disease. Int J Endocrinol. 2013;2013 689149. DOI: https://doi.org/10.1155/2013/689149

- Butler E , Matcham F , Chalder T. A systematic review of anxiety amongst people with Multiple Sclerosis. Mult Scler Relat Disord. 2016 Nov;10:145-168. DOI: https://doi.org/10.1016/j.msard.2016.10.003

- Zadro JR, Shirley D, Ferreira M, Carvalho Silva AP, Lamb SE, Cooper C, et al. Pain Physician. Is Vitamin D Supplementation Effective for Low Back Pain? A Systematic Review and Meta-Analysis. 2018 Mar; 21(2):121-145. DOI: https://doi.org/10.36076/ppj.2018.2.121

- Sommer I, Griebler U, Kien C, Auer S, Klerings I, Hammer R, et al. Vitamin D deficiency as a risk factor for dementia: a systematic review and meta-analysis. BMC Geriatr. 2017 Jan 13; 17(1):16. DOI: https://doi.org/10.1186/s12877-016-0405-0

- Luo X, Ou R, Dutta R, Tian Y, Xiong H, Shang H. Association Between Serum Vitamin D Levels and Parkinson's Disease: A Systematic Review and Meta-Analysis. Front Neurol. 2018; 9: 909. DOI: https://doi.org/10.3389/fneur.2018.00909

- Kampman MT, Wilsgaard T, Mellgren SI. Outdoor activities and diet in childhood and adolescence relate to MS risk above the Arctic Circle. J Neurol. 2007; 254:471–477. DOI: https://doi.org/10.1007/s00415-006-0395-5

- Bäärnhielm M, Olsson T, Alfredsson L. Fatty fish intake is associated with decreased occurrence of multiple sclerosis. Mult Scler. 2014; 20:726–732. DOI: https://doi.org/10.1177/1352458513509508

- Mirzaei F, Michels KB, Munger K, O'Reilly E, Chitnis T, Forman MR, et al. Gestational vitamin D and the risk of multiple sclerosis in offspring. Ann Neurol. 2011; 70:30–40. DOI: https://doi.org/10.1002/ana.22456

- Zhang Y, Leung DY, Goleva E. Anti-inflammatory and corticosteroid-enhancing actions of vitamin D in monocytes of patients with steroid-resistant and those with steroid-sensitive asthma. J Allergy Clin Immunol. 2014 Jun;133(6):1744-52. DOI: https://doi.org/10.1016/j.jaci.2013.12.004

- Hoe E, Nathanielsz J, Toh ZQ, Spry L, Marimla R, Balloch A, et al. Anti-Inflammatory Effects of Vitamin D on Human Immune Cells in the Context of Bacterial Infection. Nutrients. 2016 Dec; 8(12): 806. DOI: https://doi.org/10.3390/nu8120806

- TA, Parkes MJ, Hodgson R, Felson DT, O’Neill TW, Arden NK. Effect of Vitamin D supplementation on synovial tissue volume and subchondral bone marrow lesion volume in symptomatic knee osteoarthritis. BMC Musculoskelet Disord. 2019; 20: 76. DOI: https://doi.org/10.1186/s12891-019-2424-4

- Fatimah M. Alharbi, Update in vitamin D and multiple sclerosis. Neurosciences (Riyadh). 2015 Oct; 20(4): 329–335. DOI: https://doi.org/10.17712/nsj.2015.4.20150357

- Mowry EM. Vitamin D: evidence for its role as a prognostic factor in multiple sclerosis. J Neurol Sci. 2011 Dec 15;311(1-2):19-22. DOI: https://doi.org/10.1016/j.jns.2011.06.035

- Mesliniene S, Ramrattan L, Giddings S, Sheikh-Ali M. Role of vitamin D in the onset, progression, and severity of multiple sclerosis. Endocr Pract. 2013 Jan-Feb;19(1):129-36. DOI: https://doi.org/10.4158/EP12152.RA

- Tanja Maas 1, Chris Nieuwhof, Valeria Lima Passos, Caroline Robertson, Annelies Boonen, Robert B Landewé, et al. Transgenerational occurrence of allergic disease and autoimmunity: general practice-based epidemiological research. Prim Care Respir J2014;23(1):14–21. DOI: https://doi.org/10.4104/pcrj.2013.00108

- Weiss ST, Litonjua AA. The in-utero effects of maternal vitamin D deficiency: how it results in MS and other chronic diseases. Am J Respir Crit Care Med 2011;183(10):1286–7. DOI: https://doi.org/10.1164/rccm.201101-0160ED

- Cocco E, Meloni A, Murru MR, Corongiu D, Tranquilli S, Fadda E, et al. Vitamin D Responsive Elements within the HLA-DRB1Promoter Region in Sardinian Multiple Sclerosis Associated Alleles. PLoS One. 2012; 7(7): e41678. DOI: https://doi.org/10.1371/journal.pone.0041678

- Wingerchuk DM. Environmental factors in multiple sclerosis: Epstein-Barr virus, vitamin D, and cigarette smoking. Mt Sinai J Med. 2011 Mar-Apr; 78(2):221-30. DOI: https://doi.org/10.1002/msj.20240

- Ka S, Silva C, Pryse-Phillips W, Patten S, Metz L, Yong V. A quantitative analysis of suspected environmental causes of MS. Can J Neurol Sci 38: 98–105 DOI: https://doi.org/10.1017/S0317167100011124

- Handel A, Giovannoni G, Ebers G, Ramagopalan S. Environmental factors and their timing in adult-onset multiple sclerosis. Nat Rev Neurol. 2010 Mar;6(3):156-66. DOI: https://doi.org/10.1038/nrneurol.2010.1

- Pierrot-Deseilligny C, Souberbielle J. Is hypovitaminosis D one of the environmental risk factors for multiple sclerosis? Brain. 2010 Jul;133(7):1869-88. DOI: https://doi.org/10.1093/brain/awq147

- Orton S, Wald L, Confavreux C, Vukusic S, Krohn J, Ramagopalan S, et al. Association of UV radiation with multiple sclerosis prevalence and sex ratio in France. Neurology. 2011 Feb 1; 76(5): 425–431. DOI: https://doi.org/10.1212/WNL.0b013e31820a0a9f

- Pierrot-Deseilligny C, Souberbielle JC. Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis. Ther Adv Neurol Disord. 2013 Mar; 6(2): 81–116. DOI: https://doi.org/10.1177/1756285612473513

- Salzer J, Hallmans G, Nyström M, Stenlund H, Wadell G, Sundström P. Vitamin D as a protective factor in multiple sclerosis. Neurology. 2012 Nov 20;79(21):2140-5. DOI: https://doi.org/10.1212/WNL.0b013e3182752ea8

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Published

2022-04-19

How to Cite

Aseel Ghassan Daoud, Huda Jaber Waheed, & Mayssaa Essam Abdala. (2022). The Impact of Vitamin D on The Development of Multiple Sclerosis (Review article). Al Mustansiriyah Journal of Pharmaceutical Sciences, 21(3), 7–15. https://doi.org/10.32947/ajps.v21i3.792