Role of miRNA in drug-induced hepatic injury

Inam Sameh Arif; Israa Burhan Raoof; Hayder Hussein Luaibi; Shams Khaleel Ibraheem

doi:10.32947/ajps.v22i2.833

Authors

Inam Sameh Arif Department of Pharmacology and Toxicology
Israa Burhan Raoof Department of Clinical Laboratory Science, College of Pharmacy, Mustansiriyah University, Baghdad- Iraq
Hayder Hussein Luaibi Department of Clinical Laboratory Science, College of Pharmacy, Mustansiriyah University, Baghdad- Iraq
Shams Khaleel Ibraheem Department of Pharmacology and Toxicology

DOI:

https://doi.org/10.32947/ajps.v22i2.833

Keywords:

miRNA, hepatic injuries, Drug induce liver injuries

Abstract

Acute liver disease is characterized by loss of liver function within days or weeks however, in the patient who is not previously diagnosed, its less common compared with chronic liver failure, which developed slowly and irreversible process. It’s caused by

drug-induced liver damage (DILI) therefore identifying liver injury is challenging for clinical treatment and diagnosis. The major causes of liver failure involve toxic metabolites of some medications that consumed Adenosine Tri Phosphate (ATP) compared with normal conditions and increased oxidative stress due to overexpression of MicroRNAs, it is necessary to do complete diagnosis of patients. Biomarker parameters can be utilized to validate liver damage like microRNAs (miRNAs) analysis, it is a more receptive marker because increased earlier than the transaminases enzymes allowing for a more accurate diagnosis. we summarized recent signs of progress disease concerning the role of miRNA as a novel DILI biomarker, the miRNA levels can be measured in plasma, saliva, urine, fetal fluid (amniotic), as well as other materials either in human or animals like mice, rats which significantly elevate during illness, therefore, provide e specific biomarker of hepatoinjury.

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