Differential Effect of Cyclooxygenases 1 and 2 in Late Reproductive Age Women

  • Israa Burhan Raoof Department of Clinical Laboratory Science, College of Pharmacy, Mustansiriyah University, Baghdad- Iraq
  • Muthanna I. Al-Ezzi Department of Clinical Laboratory Science, College of Pharmacy, Mustansiriyah University, Baghdad- Iraq

Abstract

Cyclooxygenases enzymes (COX) are related with ovulation, apoptosis and menstrual disorder. Several studies demonstrate that COX 1 is one of the major sources of prostaglandin but COX 2 is more important in the late reproductive age women. Prostaglandin is bioactive compound excreted from Arachidonic


 


acid by Cox 1 and Cox 2, play role in the fertility and ovulation but when increased above the normal level especially in menstrual cycle, ectopic pregnancy is attributed to this cause. Cox 1 and Cox 2 inhibitors have been regulated the inflammatory responses include cytokines and tumor growth factors which produced from neutrophil cells by cyclooxygenases activation, it has been used to regular prostaglandin action, especially PGG2 and PGH2. Any changes in the endometrial cells lead to increased vascular inflammation that developed to the late reproductive disease. Steroidogenesis characterized by increased levels of estrogen in the uterus caused uterine infections and elevated cyclooxygenases levels especially during uterine contractions process.

Published
2019-08-01
How to Cite
RAOOF, Israa Burhan; AL-EZZI, Muthanna I.. Differential Effect of Cyclooxygenases 1 and 2 in Late Reproductive Age Women. Al-Mustansiriyah Journal of Pharmaceutical Sciences (AJPS), [S.l.], v. 19, n. 3, p. 13-18, aug. 2019. ISSN 1815-0993. Available at: <http://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/565>. Date accessed: 05 dec. 2019.