Design, Synthesis, Characterization, Biological Activity and ADME Study of New 5-arylidene-4-Thiazolidinones Derivatives Having

  • Duha E. Taha Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad-Iraq
  • Ayad M.R Raauf * Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad-Iraq
  • Karima F. Ali Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad-Iraq

Abstract

New series of Nabumetone containing 5-arylidene-4-thiazolidinones pharmacophore as in compounds 3(a-e) were designed and synthesized by using nabumetone and hydrazinethiocarboamide to synthesize compound (1) (Schiff base), next step


 


 compound (1) will react with chloroacetic acid and anhydrous sodium acetate in order to synthesize compound (2) containing 4-thiazolidinone ring this compound will react with 4-benzaldehyde derivatives in the presence of basic media such as piperidine to form compounds 3(a-e). The structures of new intermediate and final synthesized compounds were detected by determination of physical properties (melting points). The structure of synthesized compounds has been confirmed by FT-IR spectroscopy, proton nuclear magnetic resonance (1H-NMR) spectroscopy and carbon 13 nuclear magnetic resonance (13C-NMR) spectroscopy the final synthesized compounds were also screened for their antibacterial and antifungal activity.

Published
2019-12-01
How to Cite
TAHA, Duha E.; RAAUF, Ayad M.R; ALI, Karima F.. Design, Synthesis, Characterization, Biological Activity and ADME Study of New 5-arylidene-4-Thiazolidinones Derivatives Having. Al-Mustansiriyah Journal of Pharmaceutical Sciences (AJPS), [S.l.], v. 19, n. 4, p. 77-88, dec. 2019. ISSN 1815-0993. Available at: <http://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/637>. Date accessed: 15 nov. 2019.