Design, Synthesis, Characterization, Biological Activity and ADME Study of New 5-arylidene-4-Thiazolidinones Derivatives Having

Authors

  • Duha E. Taha Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad-Iraq
  • Ayad M.R Raauf * Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad-Iraq
  • Karima F. Ali Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad-Iraq

DOI:

https://doi.org/10.32947/ajps.v19i4.637

Keywords:

Nabumetone, Schiff base, 4-thiazolidinone, 5-arylidene-4-thiazolidinone, antibacterial, antifungal activity.

Abstract

New series of Nabumetone containing 5-arylidene-4-thiazolidinones pharmacophore as in compounds 3(a-e) were designed and synthesized by using nabumetone and hydrazinethiocarboamide to synthesize compound (1) (Schiff base), next step

 

 compound (1) will react with chloroacetic acid and anhydrous sodium acetate in order to synthesize compound (2) containing 4-thiazolidinone ring this compound will react with 4-benzaldehyde derivatives in the presence of basic media such as piperidine to form compounds 3(a-e). The structures of new intermediate and final synthesized compounds were detected by determination of physical properties (melting points). The structure of synthesized compounds has been confirmed by FT-IR spectroscopy, proton nuclear magnetic resonance (1H-NMR) spectroscopy and carbon 13 nuclear magnetic resonance (13C-NMR) spectroscopy the final synthesized compounds were also screened for their antibacterial and antifungal activity.

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Published

2019-12-01

How to Cite

Taha, D. E., Raauf, A. M., & Ali, K. F. (2019). Design, Synthesis, Characterization, Biological Activity and ADME Study of New 5-arylidene-4-Thiazolidinones Derivatives Having. Al Mustansiriyah Journal of Pharmaceutical Sciences, 19(4), 77–88. https://doi.org/10.32947/ajps.v19i4.637