Molecular Docking, Synthesis, Characterization and Antimicrobial Evaluation of 5-methylthiazolidine-4-ones

Authors

  • Sarmad Saadi Hussein Department of Pharmaceutical Chemistry, Collage of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
  • Karima Fadhil Ali Department of Pharmaceutical Chemistry, Collage of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
  • Fouad Abdulameer Al-Saady Department of Pharmaceutical Chemistry, Collage of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
  • Atheer Atiroğlu Biomedical, Magnetic and Semiconductor Materials Application and Research Center, Sakarya University, Sakarya, Türkiye

DOI:

https://doi.org/10.32947/ajps.v24i2.1033

Keywords:

Antimicrobial, Antimicrobial resistance, Molecular docking, Thiazolidine-4-one

Abstract

To overcome the widespread emergence of drug resistant pathological agents, newer treatment options are required to be found urgently. This research aims to design new molecules with antimicrobial activities using computational methods and to synthesize these compounds. The designed structures possessing thiazolidine-4-one heterocyclic moiety were evaluated for their in vitro antibacterial and antifungal activities and were found to exhibit antifungal and antibacterial properties. Molecular docking studies were conducted to examine the potential drug-protein interactions. Molecular characterization by spectral techniques (FT-IR, 13C NMR and 1H NMR) was carried out to confirm the identity of the synthesized compounds.

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Published

2024-04-08

How to Cite

Molecular Docking, Synthesis, Characterization and Antimicrobial Evaluation of 5-methylthiazolidine-4-ones. (2024). Al Mustansiriyah Journal of Pharmaceutical Sciences, 24(2), 163-177. https://doi.org/10.32947/ajps.v24i2.1033

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