Microsponge as a Strategy for Effective Drug Delivery System
DOI:
https://doi.org/10.32947/ajps.v23i3.1051Keywords:
Microsponge, characteristics, hypothetical mechanism, monomer, bottom to top, top to bottom, porogen.Abstract
The technology of drug delivery has become massively competitive and quickly growing. Enhancing efficacy is the primary objective of delivery system development, and hence cost-effectiveness of the treatment.
Nevertheless, controlling the rate of delivery of active pharmaceutical moieties to a target site within the body has been one of the major obstacles confronted by the drug industry. Microsponge represents a delivery system considered a promising innovation that overcomes the different challenges, since, this dosage form provides the delivery of active pharmaceutical moieties in a timely manner, in addition to responding to different stimuli (pressure, temperature, pH). Microsponge drug delivery technology proposed capturing of active moieties into tiny spongy spheres thus, donating towards reducing side effects, improving stability, increasing elegance, and enhancing formulation flexibility. The goal behind this contribution is to cover microsponge as a successful innovation, summarizing the characteristics, advantages, and limitations with certain insight into the mechanism and factors triggering the release. Furthermore, shed light on the methodology of preparation.
References
- Osmani R.A; Aloorkar N.H.; Ingale D.J.; Kulkarni PK; Hani U. and Bhosale R.R. Microsponges based novel drug delivery system for augmented arthritis therapy. Saudi Pharm J. 2015 Vol. 23. Pp :562-572 DOI: https://doi.org/10.1016/j.jsps.2015.02.020
- Rosita N.; Nailufa Y.; Hariyadi DM. Characteristics, stability and activity of epigallocatechin gallate (EGCG)- chitosan microspheres. Pp:effect of polymer concentration. Research J. Pharm. and Tech.2020 Vol. 13(5). Pp:2303-23039. DOI: https://doi.org/10.5958/0974-360X.2020.00415.1
- Subramanian S.; Anandam; S.; Kannan K; Rajappan M. Nanosponges: a novel class of drug delivery system - review. Pharm Pharm Sci. 2012; Vol. 15. Pp:103-111. DOI: https://doi.org/10.18433/J3K308
- Pallavi M. Pawashe P.M.; Patil SKS and Naikwade N.S. Prochlorperazine maleate loaded sustained release floating microspheres prepared by Ionotropic gelation technique: morphology and release characteristics. Research J. Pharm. and Tech. 2019.Vol. 12(8):3866-3872. DOI: https://doi.org/10.5958/0974-360X.2019.00664.4
- Jain N.; Sharma P.K. and Banik A. Recent Advances on microsponge delivery system. Int J Pharm Sci Rev Res. 2011.Vol. 8. Pp:13-23.
- Suchithra. A.B.; Jeganath S.; Jeevitha E. Pharmaceutical gels and recent trends –a review. Research J. Pharm. and Tech. 2019.Vol12(12) Pp:6181-6 DOI: https://doi.org/10.5958/0974-360X.2019.01073.4
- Kaity S; Maiti S; Ghosh AK; Pal D; Ghosh A and Banerjee S. Microsponges: a novel strategy for drug delivery system. J Adv Pharm Technol. 2010. Vol 1. Pp:283-290. DOI: https://doi.org/10.4103/0110-5558.72416
- Saraf A.; Dasani A.; Pathan K.H. Microsponge drug delivery system as an innovation in the cosmetic world: a review. Asian J Pharm Sci. 2012.Vol. 1(2). Pp:67-87.
- Nokhodchi A.; Jelvehgari M.; Siahi M.R. and Mozafari M.R. Factors affecting the morphology of benzoyl peroxide microsponges. Micron. 2007.Vol 38(8). Pp:834-40. DOI: https://doi.org/10.1016/j.micron.2007.06.012
- Jelvehgari M.; Siahi-Shadbad M.R.; Azarmi S.; Martin G.P and Nokhodchi A. The microsponge delivery system of benzoyl peroxide: Preparation, characterization and release studies. Int J Pharm. 2006.Vol 308. Pp:124-32. DOI: https://doi.org/10.1016/j.ijpharm.2005.11.001
- Arora N; Agarwal S. and Murthy R.S.R. Latest technology advances in cosmaceuticals. Int. J. Pharm. Sci. Drug Res. 2012.Vol 4. Pp:168-182.
- Tao Y. Development of mucoadhesive microspheres of acyclovir with enhanced bioavailability. Int J Pharm.2009. Vol.378.Pp:30-36. DOI: https://doi.org/10.1016/j.ijpharm.2009.05.025
- Mansurelahi S.K.; Koteswani P. and Srinivasa P.B. Microsponge as a novel drug delivery system. Int J Pharm Sci Rev Res. 2014. Vol.4. Pp:166-74.
- Saxena S. and Nacht S. Polymeric porous delivery systems: Polytrap and Microsponge in. Rosen M. editor. delivery system handbook for personal care and cosmetic products, technology, applications, and formulations. Ist ed. New York.William Andrew Publishing 2005. Pp. 333-335. DOI: https://doi.org/10.1016/B978-081551504-3.50021-3
- Patidar K. ; Soni M. ; Saxena C. ; Soni P. and Sharma DK. Microsponge a versatile vesicular approach for transdermal drug delivery system. J. Glob. Pharma Technol. 2009.Vol. 2(3):154-164.
- Charde S.; Ghanawat P.B.; Welankiwar A.S.; Kumar J and Chakole R.D. Microsponge a novel new drug delivery system: a review. European Journal of Molecular & Clinical Medicine 2013. Vol. 2(6). Pp:63-70.
- Mohite P.B. and Khanage S.G. Recent advances in microsponges drug delivery system. J. Crit. Rev 2016. Vol. 3(1). Pp:9-16.
- Delattre L. and Delneuville I. Biopharmaceutical aspects of the formulation of dermatological vehicles. J Eur Acad Dermatol Venereol. 1995.Vol. 5. Pp:70-71. DOI: https://doi.org/10.1016/0926-9959(95)96020-9
- Nacht S. and Kantz M. The microsponge: a novel topical programmable delivery system. Top Drug Deliv Syst. 1992. Vol.42 Pp:299-325. DOI: https://doi.org/10.1201/b14194-19
- Bamane G.S; Kakade T.B. Microsponges: a novel drug delivery system. World Journal of Pharmacy and Pharmaceutical Sciences. 2014.Vol3. Pp:748-62.
- Shukla A.; Garg A.; Garg S. Application of microsponge technique in topical drug delivery system. Asian j biomater res. 2016.Vol 2. Pp:120-6.
- Ayan K. and Banhishikha K. A novel approach on microsponge: multifunctional modern dosage form. Int J Pharm Sci Rev Res. 2018. Vol 51. Pp:64-72.
- Pradhan S.K. Microsponges as a versatile tool for the drug delivery system. Int. J. Res. Pharm. Chem. 2011.Vol. 1Pp:243-258.
- Shah V.P. Determination of in-vitro release from hydrocortisone creams. Int J Pharm. 1989; Vol.53.Pp:53-59. DOI: https://doi.org/10.1016/0378-5173(89)90361-X
- Ravi R.; Senthilkumar K.S and Parthiban S. Microsponges drug delivery system: a review. Int J Pharm Sci Rev Res. 2013. Vol. 3. Pp:6-11.
- Aritomi H.; Yamasaki Y.; Yamada K.; Honda H.; Koshi M. Development of a sustained-release formulation of chlorpheniramine maleate using powder-coated microsponges prepared by dry impact blending method. J Pharm Sci Technol. 1996. Vol. 56. Pp:49-56.
- Joshi G.; Kaur R. and Kaur H. Microsponge: a novel new drug delivery system. Int J Pharma Bio Sci 2016.Vol. 3 Pp:1-11
- Hussain H.; Juyal D. and Dhyani. A. Microsponges: an overview. Indian J Nov Drug Deliv. 2014.Vol. 6 Pp:198-207.
- Vyas S.P and Khar R.K. Targted and controlled drug delivery-novel carrier system. 1st ed. New Delhi: CBS Publication; 2002.
- Ramteke K.H; Jadhav V.B. and Dhole S.N. Microspheres:as carriers used for novel drug delivery system. IOSR J. Pharm. 2012.Vol. 2(4). Pp:44-8. DOI: https://doi.org/10.9790/3013-24204448
- Panwar A.S.; Yadav C.S.; Yadav P.; Darwhekar G.N.; Jain DK; Panwar M.S and Agarwal A. Microsponge a novel carrier for cosmetics. J Global Pharma Technology. 2011.Vol. 3. Pp:1524.
- Kumar S.; Bhatt D.C. Influence of sodium alginate and calcium chloride on the characteristics of Isoniazid loaded nanoparticles. Research J. Pharm. and Tech. 2021. Vol.14(1) Pp:389-396. DOI: https://doi.org/10.5958/0974-360X.2021.00071.8
- Shaha V.; Hitesh Jain H.; Krishna J. and Patel P. Microsponge drug delivery system: A review. Int J Res Pharm Sci. 2010. Vol. 1. Pp :212-18.
- Parthiban K.G. Manivannan R. Krishnarajan D.; Chandra S. and Nidhin Raj. Microsponge role in novel drug delivery system. Int J Pharm Res Dev.2011; Vol. 3. Pp:117-125.
- Shinkar D.M.; Paralkar P.S.; Saudagar R.B. An overview on trends and developments in liposome – as drug delivery system. Asian J. Pharm. Tech. 2015. Vol. 5(4). Pp:231-7. DOI: https://doi.org/10.5958/2231-5713.2015.00033.1
- Shyam S.M.; Vedavathi T. Novel approach: microsponge drug delivery system. Int J Pharm Sci Res. 2012; 3. Pp:967-80.
- Srivastava R.; Pathak K. Microsponges: a futuristic approach for oral drug delivery. Expert Opin. Drug Delivery. 2012: Vol.9. Pp:863-878. DOI: https://doi.org/10.1517/17425247.2012.693072
- Patel S.; Patel M. and Patel M. Formulation and evaluation of microsponge based nicorandil sustained released tablet. J Sci Res. 2017. Vol. 9. Pp :285. DOI: https://doi.org/10.3329/jsr.v9i3.31193
- Mahajan A.G; Jagtap L.S; Chaudhari A.L.; Swami S.P.; Mali P. Formulation and evaluation of the microsponge drug delivery system using indomethacin. Int Res J Pharm. 2011. Vol. 2. Pp:64-69.
- Kumar S. Innovative and novel strategy: microsponges for topical drug delivery. J drug deliv Ther. 2018.Vol.8. Pp:28-39. DOI: https://doi.org/10.22270/jddt.v8i5.1885
- Nawal A. Formulation and in vitro Evaluation of piroxicam microsponges as a tablet. Int J Pharm Pharm Sci. 2018.Vol. 8. Pp:104-114
- Pawar A.P.; Gholap A.P.; Kuchekar A.B.; Bothiraja C. and Mali A.J. Formulation and evaluation of optimized oxybenzone microsponge gel for topical delivery. J Drug Deliv. 2015. Pp: 261-68. DOI: https://doi.org/10.1155/2015/261068
- Dev A.; Dwivedi J.; Momin M. Quality by Design based formulation and evaluation of acyclovir microsponges. Journal of Drug Delivery &Therapeutics. 2019. Vol.9.Pp:54-60. DOI: https://doi.org/10.22270/jddt.v9i1.2159
- Deshmukh R.; Naik J. Diclofenac sodium-loaded eudragit (R) microspheres: optimization using statistical experimental design. J Pharm Innov. 2013. Vol. 8. Pp:276-87. DOI: https://doi.org/10.1007/s12247-013-9167-9
- Leyden J.; Tanghetti E.; Miller B.; Ung M.; Berson D. and Lee J. Once-daily tazarotene 0.1 % gel versus once-daily tretinoin 0.1 % microsponge gel for the treatment of facial acne vulgaris: a double-blind randomized trial. Cutis. 2002.Vol. 69. Pp:12-19.
- Ashlesha P.; Saurabh P.; Vandana B.; Vinit K. and Vrushali K. Nebivolol-loaded microsponge gel for healing of diabetic wound. AAPS Pharm SciTech. 2016.Vol.18. Pp:846-54. DOI: https://doi.org/10.1208/s12249-016-0574-3
- Patel N.; Padia N.; Vadgama; N. Raval M.; Sheth N. Formulation and evaluation of microsponge gel for topical delivery of fluconazole for fungal therapy. J Pharm Investig. 2016.Vol. 46. Pp:221-238. DOI: https://doi.org/10.1007/s40005-016-0230-7
- Mahaparale P; Ikam S; Chavan M. Development and evaluation of terbinafine hydrochloride polymeric microsponges for topical drug delivery. Indian J Pharm Sci. 2018.Vol. 80:1086-1092. DOI: https://doi.org/10.4172/pharmaceutical-sciences.1000459
- Amrutiya N.; Bajaj A. and Madan M. Development of microsponges for topical delivery of mupirocin. AAPS Pharm Sci Tech. 2009.Vol. 10:402-409. DOI: https://doi.org/10.1208/s12249-009-9220-7
- Kumar P.M. and Ghosh A. Development and evaluation of silver sulfadiazine loaded microsponge based gel for partial thickness (second degree) burn wounds. Eur J Pharm Sci. 2017. Vol. 96. Pp:243-54. DOI: https://doi.org/10.1016/j.ejps.2016.09.038
- Grimes Pl. A microsponge formulation of hydroquinone 4% and retinol 0.15% in the treatment of melasma and post-inflammatory hyperpigmentation. Cutis. 2004.Vol.74(6) Pp:362-368
- Wadhwa G, Kumar S., Mittal V. and Rao R. Encapsulation of babchi essential oil into microsponges: Physicochemical properties, cytotoxic evaluation, and anti-microbial activity. J Food Drug Anal. 2019.Vol. 27. Pp:60-70. DOI: https://doi.org/10.1016/j.jfda.2018.07.006
- Jadhav N.; Patel V.; Mungekar S.; Karpe M. and Kadam V. Microsponge delivery system: an updated review; current status and future prospects. Journal of Scientific and Innovative Research. 2013.Vol. 2. Pp:1097-110
- Gupta A.; Tiwari G.; Tiwari R. and Srivastava R. Factorial designed 5-fluorouracil-loaded microsponges and calcium pectinate beads plugged in hydroxypropyl methylcellulose capsules for colorectal cancer. Int J Pharm Investig. 2015.Vol. 5. Pp :234-46. DOI: https://doi.org/10.4103/2230-973X.167688
- Beruto D.; Botter R.; Fini M. The effect of water in inorganic microsponges of calcium phosphates on the porosity and permeability of composites made with polymethyl methacrylate. Biomaterials. 2002 Vol. 23. Pp:2509-2517. DOI: https://doi.org/10.1016/S0142-9612(01)00385-4
- Iwai S.; Sawa Y.; Ichikawa H.; Taketami S.; Uchimura E. and Chen G. Biodegradable polymer with collagen microsponge serves as a new bioengineered cardiovascular prosthesis. J Thorac Cardiovasc Surg. 2004.Vol. 128. Pp:472-479. DOI: https://doi.org/10.1016/j.jtcvs.2004.04.013
- Akita S.; Akino K.; Tanaka K.; Anraku K. and Hirano A. A basic fibroblast growth factor improves lower extremity wound healing with a porcine-derived skin substitute. J Trauma Inj. 2008. Vol. 64. Pp :809-815. DOI: https://doi.org/10.1097/TA.0b013e31802c8247
- Chen G; Ushida T. and Tateishi T. Poly (DL‐lactic‐co‐glycolic acid) sponge hybridized with collagen microsponges and deposited apatite particulates. J Biomed Mater Res. 2001. Vol. 57. Pp:8-14. DOI: https://doi.org/10.1002/1097-4636(200110)57:1<8::AID-JBM1135>3.0.CO;2-H
- Neamah W.F; Maraie N.K and Al-Timmemi H.A. Intravitreal implantable film containing ketorolac tromethamine microsponges in vitro/in vivo correlation. Sys Rev Pharm. 2020. Vol.11. Pp:313- 321. DOI: https://doi.org/10.31838/srp.2020.5.46
- Sethi R.K.; Sahoo S.K.; Das P.K. and Barik B.B. Effect of dispersing agent on the characteristics of eudragit microspheres. Research J. Pharma. Dosage Forms and Tech. 2010. Vol. 2. Pp:67-71.
- Tiwari A., Tiwari V., Palaria B., Kumar M. and Kaushik D. Microsponges: a breakthrough tool in pharmaceutical research. Future Journal of Pharmaceutical Sciences .2022. Vol. 8 (31). Pp:1-25. DOI: https://doi.org/10.1186/s43094-022-00421-9
- Mothe P.B.; Khange S.G.; Harishchandre V.S. and Yogita S. Recent advance in microsponge drug delivery. J Crit Rev tem. 2016; 3:9-16.
- Pandey P.; Jain V. and Mahajan S.C. A review: microsponge drug delivery system. Int J Biopharm. 2013.Vol 4. Pp:225-30.
- Upadhyay M.S. and Pathak K. Glyceryl monooleate-coated bioadhesive hollow microspheres of riboflavin for improved gastroretentivity: Optimization and pharmacokinetics. Drug Deliv Transl Res. 2013. Vol. 3. Pp:209-223. DOI: https://doi.org/10.1007/s13346-013-0143-1
- Christensen M.S.; Natch S.J. Invest. Dermato. 1983; 69:282.
- Reddy K.V.R.; Nagabhushanam M.V and Naik E.R. Swellable hydrogels and crosslinking Agents - Their role in drug delivery system. Research J. Pharm. and Tech.2017.Vol 10(3):Pp937-949
- Hussien A.H. Preparation and evaluation of oral microsponge drug delivery system of ketoconazole. Al Mustansiriyah Journal of Pharmaceutical Sciences.2014. Vol. 14. (1).Pp: 1-8 DOI: https://doi.org/10.32947/ajps.v14i1.119
- Jayaweera D.M. Medicinal Plants (Indigenous and exotic) used in Ceylon. Part-II. Colombo, Natural Sciences Council of Sri Lanka ;1980.
- Mishra M. Microsponge: An augmented drug delivery system. Am. J. Pharm Tech Res. 2016. Vol.6(6). Pp:80-94.
- Chadawar V.; Shaji J. Microsponge delivery system. Curr. Drug Deliv. 2007.Vol. 4. Pp:123-129. DOI: https://doi.org/10.2174/156720107780362320
- Mani; Shankar. A Current View on microsponge drug delivery system. European Journal of Molecular Biology and Biochemistry. 2016.Vol 3. Pp:33.
- Shrivastava S.; Kumar D.; Dubey C.; Singh S. and Khinchi M. A Review: Microsponge-an effective drug delivery system. Asian J. Pharm. Res. Dev. 2017.Vol 5.Pp:1-08.
- Sato T.; Kanke M.; Schroeder G. and Deluca P. Porous biodegradable microspheres for controlled drug delivery. Assessment of processing conditions and solvent removal techniques. Pharm Res.1988. Vol. 5. Pp :21-30. DOI: https://doi.org/10.1023/A:1015855210319
- Abdul Ameer M.W. and Maraie N.M. Preparation and Evaluation of Microencapsulated Dexamethasone Sodium Phosphate Using Double Emulsion Method. Al Mustansiriyah Journal of Pharmaceutical Sciences. 2019. Vol.19. (1) Pp:1-11 DOI: https://doi.org/10.32947/ajps.v19i1.539
- Draize J.H; Woodard G.; Calvery H.O. Methods for the study of irritation and toxicity of substance es applied topically to the Skin and Mucous Membranes. J Pharmacol Exp Ther. 1944.Vol. 82. Pp:377-389.
- Embil K. and Nacht S. The microsponge delivery system (MDS): A topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives. J. Microencapsul.1996; 3 Pp:575-88. DOI: https://doi.org/10.3109/02652049609026042
- Friedrich H. Ion Exchange.1st ed. NY. Dover publishing inc; 1995.
- Grochowicz M.; Bartnicki A. and Gawdzik B. Preparation and characterization of porous polymeric microspheres obtained from multifunctional methacrylate monomers. J Polymer Sci. 2008.Vol. 46. Pp:6165-6174. DOI: https://doi.org/10.1002/pola.22927
- Kawashima Y.; Niwa T.; Takeuchi H.; Hino T. and Ito Y. Control of prolonged drug release and compression properties of ibuprofen microsponges with acrylic polymer; eudragit RS; by changing their intraparticle porosity. Chem. Pharm. Bull.1992; 40:196-201. DOI: https://doi.org/10.1248/cpb.40.196
- Akiladevi; Elango K. and Basak S. Preparation and in vitro controlled release characteristics of salbutamol microcapsules by coacervation phase separation technique. Research J. Pharm. and Tech.2011. Vol.4(2). Pp:276-278
- Comoglu T.; Gonul N; and Baykara T. Preparation and in vitro evaluation of modified release ketoprofen microsponges. Farmaco. 2003. Vol.58. Pp:101-106. DOI: https://doi.org/10.1016/S0014-827X(02)00007-1
- D"souza J.I. and More H.N. Topical anti-inflammatory gels of flucinolone acetonide entrapped in eudragit based microsponge delivery system. Res J Pharm Technol. 2008.Vol. 1. Pp:502-506.
- Rosadiani D.W.; Purwanti T. and Purwanto DA. Effect of natrium alginate concentration on physical characteristics: viability and anticancer activity of microparticles from a combination of probiotics and tomato pasta. Research J. Pharm. and Tech. 2018. Vol.11(6). Pp:2575-2580 DOI: https://doi.org/10.5958/0974-360X.2018.00476.6
- Liu L-S.; Liu S-Q.; Ng S.Y.; Froix M.; Ohno T. and Heller J. Controlled release of interleukin-2 for tumour immunotherapy using alginate/chitosan porous microspheres. J Control Release. 1997. Vol. 43. Pp:65-74. DOI: https://doi.org/10.1016/S0168-3659(96)01471-X
- Sahumena M.H.; Mabilla S.Y.; Ningsih S.R.; Adjeng A.N.; Aswan M. and Nisa M. Preparation and evaluation of physical characteristics of vitamin E nanoemulsion using virgin coconut Oil (VCO) and olive oil as oil phase with variation concentration of tween 80 surfactant. Research Journal of Pharmacy and Technology. 2020.Vol.13(7) Pp:3232-3236. DOI: https://doi.org/10.5958/0974-360X.2020.00572.7
- Jadhav N.; Vruti Patel V.; Siddesh M.; Bhamare G.; Karpe M. and Kadams V. Microsponge delivery system: An updated review, current status and future prospects. Journal of Scientific and Innovative Research. 2013. Vol.2. (6). Pp:1097-1110
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