A Review of Herbal and Medicated Lipsticks: The General Cons and The Metal Contamination

Authors

  • Zahraa Hassan Abed Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University
  • Masar Basim Mohsin Mohamed Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University
  • Lina A. Dahabiyeh Department of Pharmaceutical Sciences, School of Pharmacy, The University of Amman ، Jordan

DOI:

https://doi.org/10.32947/ajps.v25i4.1276

Keywords:

Herbal, medicated lipstick, acyclovir, lanolin, metal contamination

Abstract

Medicated lipsticks use active medicinal compounds in lipstick formulations to combine therapeutic advantages with cosmetic benefits such as hydrating, mending, and shielding the lips against infections, dryness, and chapping. A shed of light on the materials used, such as waxes, oils, and pigments.

Also, this review provided an overview of previous research that clarified the usage of various constituents in lipstick and the production methods.  A focus on herbal and medicate lipsticks such as lipstick formulations of antifungal agents (e.g. ketoconazole), antiviral (e.g. acyclovir), sunscreens, vitamin D3, and moisturizers like vitamin E and lanolin. Lipstick’s effectiveness can be investigated through many studies, such as melting point, softening point, breaking point, thixotropy, the force of application, separability, pH meter, skin irritation, and stability. Additionally, metal contaminants are due to ingredients impurities and attention to the use of advanced analytical instruments to analyse the presence of lead and other metals in lipstick formulation based on their considerable impact on consumer health.

References

1- Munawiroh, S.Z., A.N. Nabila, and L.J.I.J.P.M.B.S. Chabib, Development of water in olive oil (W/O) Nanoemulsions as lipstick base formulation. 2017. 6(2): p. 37-42.

2- Bijauliya, R.K., et al., A comprehensive review on herbal cosmetics. 2017. 8(12): p. 4930-4949.

3- Rasheed, N., et al., Formulation and evaluation of herbal lipsticks. 2020. 13(4): p. 1693-1700.

4- Mawazi, S.M., et al., Lipsticks history, formulations, and production: a narrative review. 2022. 9(1): p. 25.

5- Saha, R.J.I.J.o.P.S. and Research, Cosmeceuticals and herbal drugs: practical uses. 2012. 3(1): p. 59.

6- Afandi, A., et al., Antibacterial properties of crude aqueous Hylocereus polyrhizus peel extracts in lipstick formulation against gram-positive and negative bacteria. 2017. 46(2): p. 29-34.

7- Shaikh, S. and K.J.A.J.o.P. Bhise, Formulation and evaluation of medicated lipstick of allantoin. 2008. 2(2): p. 91.

8- Rajalakshmi, S. and O.J.I.J.A.P. Vinaya, Formulation development, evaluation and optimization of medicated lip rouge containing niosomal acyclovir for the management of recurrent herpes labialis. 2017. 9(6): p. 21-27.

9- Mishra, P. and S.J.A.J.M.P.R. Dwivedi, Formulation and evaluation of lipstick containing herbal ingredients. 2012. 2(3): p. 58-60.

10- Santos, J.J.I.J.P.B., A study on the medicinal usage of flora and fauna by Ganifuna community in Belize. 2013. 4(3): p. 139-144.

11- Andersen, F.J.I.J.o.T., Safety assessment of salicylic acid, butyloctyl salicylate, calcium salicylate, C12-15 alkyl salicylate, capryoyl salicylic acid, hexyldodecyl salicylate, isocetyl salicylate, isodecyl salicylate, magnesium salicylate, MEA-salicylate, ethylhexyl salicylate, potassium salicylate, methyl salicylate, myristyl salicylate, sodium salicylate, TEA-salicylate, and tridecyl salicylate. 2003. 22(supplement 3): p. 1-108.

12- Sathish, S., et al., Preparation and evaluation of salicylic acid medicated lipstick. 2012. 2(2): p. 289-94.

13- Dalapati, N., P.K. Kar, and S.J.W.J.O.P.R. Panda, Preparation And Evaluation Of Herbal Lipstick. 2018. 7(9).

14- Łodyga-Chruścińska, E., A. Sykuła, and M.J.C. Więdłocha, Hidden metals in several brands of lipstick and face powder present on polish market. 2018. 5(4): p. 57.

15- Veludurthi, P.A., A.K.J.J.o.P.I. Vadaga, and Research, A Comprehensive Review of Formulations, Ingredients, Advances, and Future Perspectives in Lipcare Cosmetics. 2024. 2(3): p. 123-128.

16- McMullen, R.L., Antioxidants and the Skin. 2018: CRC Press.

17- Kwatra, S., G. Taneja, and N.J.I.G.J.o.P.S. Nasa, Alternative routes of drug administration-transdermal, pulmonary & parenteral. 2012. 2(4): p. 409-426.

18- Parth, S., G.J.R. Bhupendra, and R.H.C.O.A. J, Topical “Medistick” Of Antifungal, the New Future of Drug-Cosmetic. 2018. 1(3).

19- Esposito, C.L. and P.J.G. Kirilov, Preparation, characterization and evaluation of organogel-based lipstick formulations: Application in cosmetics. 2021. 7(3): p. 97.

20- LIP-TX, B., Lips need special treatment.

21- Madhav, N. and A.J.I.J.P.P.S. Ojha, Labial mucosa as novel transmucosal drug delivery platform. 2012. 4(3): p. 83-90.

22- Mehrotra, S. and K.J.T.D. Pathak, Translabial drug delivery: potential and possibilities. 2020, Taylor & Francis. p. 673-676.

23- NV, M.S. and A.P.J.J.o.P.R. Yadav, Lip: An impressive and idealistic platform for drug delivery. 2011. 4(4): p. 1060-1062.

24- Bhairy, S.R., et al., Translabial route: a novelistic platform for systemic drug delivery. 2016. 4(7): p. 840-861.

25- McIntosh, K., et al., Alkenones as a promising green alternative for waxes in cosmetics and personal care products. 2018. 5(2): p. 34.

26- Patil, C., et al., Formulation and evaluation of sugar cane wax based lipstick. 2019. 3(5): p. 827-829.

27- Gediya, S.K., et al., Herbal plants: used as a cosmetics. 2011. 1(1): p. 24-32.

28- Kothari, R., et al., Formulation and evaluation of herbal lipstick from natural edible coloring matter. 2018. 10(1): p. 17-20.

29- Mouna, A., et al., Formulation and Evaluation of Herbal Lipstick Containing Saffron as a Natural Colorant. 2023. 23(4): p. 406-410.

30- Azwanida, N., et al., Color stability evaluation of pigment extracted from Hylocereus polyrhizus, Clitorea ternatae and Pandanus amaryllfolius as cosmetic colorants and Premarket survey on customer acceptance on natural cosmetic product. 2015. 3(1): p. 61-67.

31- Gawade, P., et al., Beetroot powder loaded medicated lip balm.

32- Sainath, M., K.S. Kumar, and K.A.J.I. Babu, Formulation and evaluation of herbal lipstic. 2016. 3: p. 2058-2060.

33- Yadav, S., V. Redasani, and K.J.W.J.P.R. Baid, Formulation and evaluations of herbal lipstick. 2020. 9(4): p. 1436-44.

34- Hayati, F., L.J.I.J.o.P. Chabib, and P. Sciences, Formulation And Evaluation Of Herbal Lipsticks From Carrot (Daucus carota L) Extract'. 2016. 8(3): p. 403-405.

35- Bhagwat, D., et al., Formulation and evaluation of herbal lipstick using lycopene extracted from Solanum lycopersicum L. 2017. 10(4): p. 1060-1064.

36- Tuñón-Molina, A., et al., Antimicrobial Lipstick: Bio-Based Composition against Viruses, Bacteria, and Fungi. 2022. 14(51): p. 56658-56665.

37- Poomanee, W., et al., Application of factorial experimental design for optimization and development of color lipstick containing antioxidant-rich Sacha inchi oil. 2021. 34(4): p. 1437-1444.

38- Harshad, S., A.J.I.I.J.o.M. Wankhade, and P. Sciences, Design and characterization of Nutraceutical lipstick of Beetroot Powder. 2019. 4(2): p. 1-4.

39- Sivakumar, P., et al., Nutritional value, phytochemistry, pharmacological and in vitro regeneration of turmeric (Curcuma longa L.): An updated review. 2022. 11(1): p. 236-246.

40- Maktabi, B., M.W. Liberatore, and G.J.I.J.o.C.S. Baki, Meadowfoam seed oil as a natural dispersing agent for colorants in lipstick. 2021. 43(4): p. 484-493.

41- Muley, B., S. Khadabadi, and N.J.T.j.o.p.r. Banarase, Phytochemical constituents and pharmacological activities of Calendula officinalis Linn (Asteraceae): a review. 2009. 8(5).

42- Lin, T.-K., L. Zhong, and J.L.J.I.j.o.m.s. Santiago, Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. 2017. 19(1): p. 70.

43- Rao, J. and D.J.J.F.c. McClements, Impact of lemon oil composition on formation and stability of model food and beverage emulsions. 2012. 134(2): p. 749-757.

44- Komane, B., et al., Safety and efficacy of Sclerocarya birrea (A. Rich.) Hochst (Marula) oil: A clinical perspective. 2015. 176: p. 327-335.

45- Chaiyana, W., et al., Herbal extracts as potential antioxidant, anti‐aging, anti‐inflammatory, and whitening cosmeceutical ingredients. 2021. 18(7): p. e2100245.

46- Cavanagh, H. and J.J.P.r. Wilkinson, Biological activities of lavender essential oil. 2002. 16(4): p. 301-308.

47- Evangelista, M.T.P., F. Abad‐Casintahan, and L.J.I.j.o.d. Lopez‐Villafuerte, The effect of topical virgin coconut oil on SCORAD index, transepidermal water loss, and skin capacitance in mild to moderate pediatric atopic dermatitis: a randomized, double‐blind, clinical trial. 2014. 53(1): p. 100-108.

48- Worrall, G.J.B.c.e., Herpes labialis. 2009. 2009.

49- Khudhair, D.B. and W.K.J.A.M.J.o.P.S. Ali, Formulation and evaluation of Acyclovir compressed lozenges. 2020. 20(4): p. 35-44.

50- Devaraj, G.N., et al., Release studies on niosomes containing fatty alcohols as bilayer stabilizers instead of cholesterol. 2002. 251(2): p. 360-365.

51- Prajapati, B.G., H. Paliwal, and P.A.J.F.J.o.P.S. Shah, In vitro characterization of self-emulsifying drug delivery system-based lipsticks loaded with ketoconazole. 2023. 9(1): p. 35.

52- Pan, S., et al., Candidate formulations for a sustainable lipstick supplemented with vitamin D3: effects of wax type and concentration on material properties. 2021. 60(5): p. 2027-2040.

53- Lim, T., T.J.E.M. Lim, and F. Non-Medicinal Plants: Volume 5, Zea mays. 2013: p. 416-447.

54- Madhav, N. and A.J.I.R.J.P. Yadav, Development and evaluation of novel repaglinide biostrips for translabial delivery. 2013. 4: p. 198-202.

55- Madhav, N.S. and A.P.J.A.P.S.B. Yadav, A novel translabial platform utilizing bioexcipients from Litchi chinesis for the delivery of rosiglitazone maleate. 2013. 3(6): p. 408-415.

56- Al Faysal, A., et al., Development and Fabrication of a Molecularly Imprinted Polymer-Based Electroanalytical Sensor for the Determination of Acyclovir. 2024. 9(8): p. 9564-9576.

57- Tirunagari, M., et al., Formulation and evaluation of medicated lipstick using natural coloring agent. 2020. 11(1): p. 20-23.

58- Sunil, R., T.C. Shekhar, and B.J.I.J.o.P.E. Ashutosh, Formulation and evaluation of a herbal lipstick: A new approach. 2013. 3(1): p. 26-30.

59- Azwanida, N., N. Normasarah, and A.J.J.T. Afandi, Utilization and evaluation of betalain pigment from red dragon fruit (Hylocereus Polyrhizus) as a natural colorant for lipstick. 2014. 69(6).

60- Reddy, S., et al., Formulation evaluation development and validation of simultaneous equation method for estimation of vitamin c and vitamin d in multivitamin lipstick. 2020. 10(2).

61- Ng, H.W., P. Cottin, and S. Tamburic, Optimisation of the wax and oil phases in a conventional lipstick using mixture design. 2014.

62- Bakrudeen, H.B., et al., Preparation and evaluation of natural lipstick from beetroot (Beta vulgaris) extract medicated with acyclovir. 2024. 31(3): p. 337-345.

63- Chee, S.Y.K. and H.J.T.F.C.P.B.A.D.P.D.U.N.F.C. Sarini, Effect of cocoa wax derived from free fatty acids of cocoa butter deodorizer distillate towards physical properties of lipstick. 2018. 10: p. 107.

64- Jain, M. and S.J.A.J.o.L.S.R. SumeetDwivedi, Design, development and characterization of herbal lipstick containing natural ingredients. 2017. 5(2): p. 36-39.

65- Yuliawati, A.N. and K.D.J.M.O.T. Cahyadi, Formulation, physical quality evaluation, and antioxidant activity of body butter of ethanol extract of dragon fruit (hylocereus polyrhizus) peel. 2020. 25(3): p. 146-153.

66- Tan, Y.L., Preparation of Lipstick With Red Draon Fruit (Holycereus Polyrhizus) Pigment And Storage Stability Study. 2020, UTAR.

67- Fernandes, A.R., et al., Stability evaluation of organic Lip Balm. 2013. 49: p. 293-299.

68- Nareswari, T.L., E. Syafitri, and O.J.P.R. Nurjannah, Sunscreen lip balm stick formulation containing a combination of virgin coconut oil and crude palm oil. 2022. 2(2): p. 48-48.

69- Lambers, H., et al., Natural skin surface pH is on average below 5, which is beneficial for its resident flora. 2006. 28(5): p. 359-370.

70- Norazlin, M.M.H.J.A.J.o.P., Improved properties of lipstick formulation with engkabang fats. 2015: p. 125-128.

71- Mustarichie, R. and D.J.D.I.T. Gozali, Lip color formulation using mangosteen rind extract (Garcinia mangostana L.). 2019. 11(11).

72- Lwin, T., et al., Formulation and evaluation of lipstick with betacyanin pigment of Hylocereus polyrhizus (Red Dragon Fruit). 2020. 10(4): p. 212-224.

73- Heldermann, M.J.S.A.P. and C. Review, How to get the perfect lipstick: Colour cosmetics. 2017. 44(1): p. 22-23.

74- Bocca, B., et al., Toxic metals contained in cosmetics: a status report. 2014. 68(3): p. 447-467.

75- Maibach, H.I. and T. Menné, Nickel and the skin: immunology and toxicology. 1989: CRC Press.

76- Hostynek, J.J. and H.I.J.R.o.e.h. Maibach, Copper hypersensitivity: dermatologie aspects. 2003. 18(3): p. 153-184.

77- Okamoto, M., et al., Fast analysis of trace amounts of lead in cosmetics by atomic absorption spectrophotometry. 1971. 22: p. 589-598.

78- Liu, S., S.K. Hammond, and A.J.E.H.P. Rojas-Cheatham, Concentrations and potential health risks of metals in lip products. 2013. 121(6): p. 705-710.

79- Lee, B.-M., et al., Perspectives on trace chemical safety and chemophobia: risk communication and risk management. 2019. 82(3): p. 186-199.

80- Cummings, M.K., Ensuring cosmetic and personal care product quality and safety in a self-regulated industry. 2001: California State University, Dominguez Hills.

81- Zakaria, Z., Cosmetic safety regulations: a comparative study of Europe, the USA and Malaysia. 2013: The University of Manchester (United Kingdom).

82- Dahiya, S., Y.G. Rokshi, and C.J.I.J.P.E.R. Sharma, Quality Concerns of Lip Care Cosmetics and Applicable Regulatory Framework: Need for a Harmonized Cosmetovigilance Programme. 2024. 58(1s): p. s1-s8.

83- Authority, E.F.S., E.C.f.D. Prevention, and C.J.E. journal, The European Union one health 2018 zoonoses report. 2019. 17(12): p. e05926.

84- FDA, U., FDA authority over cosmetics: how cosmetics are not FDA-approved, but are FDA-regulated. 2018.

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Published

2025-10-30

How to Cite

A Review of Herbal and Medicated Lipsticks: The General Cons and The Metal Contamination. (2025). Al Mustansiriyah Journal of Pharmaceutical Sciences, 25(4), 663-681. https://doi.org/10.32947/ajps.v25i4.1276

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