Synthesis, Characterization and Antibacterial Studies of 2-azetidinones Compounds Derived from Amoxicillin

Entesar Obeed AL-Tamimi; Raad Mahjoub Muslih; Khalida Ali Thejeel

doi:10.32947/ajps.v15i1.160

Synthesis, Characterization and Antibacterial Studies of 2-azetidinones Compounds Derived from Amoxicillin

Authors

Entesar Obeed AL-Tamimi Department of Chemistry, College of Science, University of Baghdad
Raad Mahjoub Muslih Department of Chemistry, College of Science for Women, University of Baghdad
Khalida Ali Thejeel Department of Pharmaceutical Chemistry, College of Pharmacy, University of AL-Mustansria

DOI:

https://doi.org/10.32947/ajps.v15i1.160

Keywords:

Schiff bases, azetidinones, synthesis, antibacterial activity

Abstract

In this study, the new azetidinones were synthesized from Schiff bases 2(a-j) that derived from amoxicillin (1) on treatment with chloroacetyl chloride in presence of triethylamine gave azetidinone 3(a-j). The structure of these compounds have been elucidated on the basis of their physical and spectral. Azetidinone compounds were also screened for their antibacterial activity against some bacterial species using amoxicillin as standard.

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Published

2015-06-01

How to Cite

AL-Tamimi, E. O., Muslih, R. M., & Thejeel, K. A. (2015). Synthesis, Characterization and Antibacterial Studies of 2-azetidinones Compounds Derived from Amoxicillin. Al Mustansiriyah Journal of Pharmaceutical Sciences, 15(1), 14–23. https://doi.org/10.32947/ajps.v15i1.160

Issue

Vol. 15 No. 1 (2015): volume 15, Issue 1. 2015

Section

Articles

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