In vitro study of Phytic acid effect on p53 protein in cancer line

Rafal Hussamildeen Abdullah

doi:10.32947/ajps.v12i2.231

In vitro study of Phytic acid effect on p53 protein in cancer line

Authors

Rafal Hussamildeen Abdullah Department of experimental therapy, Iraqi center for cancer research andmedical genetics, Al- Mustanseria University

DOI:

https://doi.org/10.32947/ajps.v12i2.231

Abstract

Studying Phytic acid cytotoxic effect on cancer cell line showed that it is a concentration dependant effect on cancer cell line in compare with control, also
have effect on the production of p53 protein using protein detection method using Eliza.
The concentration of p3 protein is decreased in Vero with no significant effect (34 pg/ml ± SD 4) compare with control (64pg/ml ±SD 4) p > 0.05.
Radomyosarcoma cell line (232 pg/ml± SD 32) shows a significant increase in compare with control (686 pg/ml ± SD 86) p> 0.05. The production of p53 increase in Glioblastoma- Multiforme cell (118 pg/ml ± SD 18) in compare with control (38 pg/ml ± SD 8), while the p53 quantity was not affected in the Ahmed Mohamed Nahi 3 (40 pg/ml± SD 10) compare with control (44 pg/ml ± SD 4) p>0.05.which show a different inhibition mechanisms of action on cancer cell line.

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Published

2012-12-01

How to Cite

Abdullah, R. H. (2012). In vitro study of Phytic acid effect on p53 protein in cancer line. Al Mustansiriyah Journal of Pharmaceutical Sciences, 12(2), 35–42. https://doi.org/10.32947/ajps.v12i2.231

Issue

Vol. 12 No. 2 (2012): volume 12,Issue 2. 2012

Section

Articles

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