In Situ Hybridization probing by Transforming Growth Factor β1 marker during prenatal period for rat's primary visual cortex

Authors

  • Mustafa Mohammed Ibraheem Department of Anatomy, Histology and Embryology, College of Medicine, Al-Mustansiriya University

DOI:

https://doi.org/10.32947/ajps.v12i2.263

Abstract

The objective of this study is to recount the prenatal developmental changes of the primary visual cortex with the space and time appearance of the activity of
the studied marker through In Situ Hybridization technique. TGF-β1 has a multitude of functions, including both promoting the formation and inhibiting the
breakdown of connective tissue with inhibition of epithelial cell proliferation. Eighteen embryos were used; three embryos for each of the following gestational days (G15, G16, G17, G18, G19 and G20). The reaction was gradual and followed an inside-out gradient from deep to superficial laminae of the rat's primary visual cortex.
Cell migration was altered by TGF-β1 in a concentration-dependent manner: at low concentrations, cell migration was promoted whereas at high concentrations, migration was impeded. Therefore, it is an important regulator of the cell behavior throughout prenatal age.

 

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Published

2012-12-01

How to Cite

Ibraheem, M. M. (2012). In Situ Hybridization probing by Transforming Growth Factor β1 marker during prenatal period for rat’s primary visual cortex. Al Mustansiriyah Journal of Pharmaceutical Sciences, 12(2), 178–188. https://doi.org/10.32947/ajps.v12i2.263