Lipid Profile and Essential Fatty Acid Concentration in Typhoid Fever Patients

Abstract

The activation of inflammatory cells, the release of their mediators, and the excessive production of free radicals may affect circulating lipids, while no evidence supports a role for peroxidation in the pathogenesis of typhoid fever disease.

Lipid profile and essential fatty acids concentration were measured in 44 typhoid fever patients and 25 healthy controls.
The proportion of saturated and monounsaturated fatty acids were found to be higher in serum of typhoid fever patients, in contrast with polyunsaturated
fatty acids which were found to be lower in those patients when compared with healthy controls, this results in a higher ratio of palmitoleic acid to linoleic acid
(P<0.04) and of eicosatrienoic acid to arachidonic acid (P<0.03) (Table-2).
Typhoid fever patients showed also hypocholesterolemia and hyper LDLcholesterolemia (P<0.001 and P<0.003 respectively) (Table-1, Fig.-1).
Regarding triglycerides and HDL–cholesterol, they demonstrated a non significant change in typhoid fever.
In conclusion, typhoid fever patients showed some disturbances in their lipid profile and essential fatty acid concentration which may be of clinical significance.
Objective To show the effect of typhoid fever on lipid profile and essential fatty acids concentration