Using of Sintering and Microwave Techniques to Control the Release of Trifluoperazine HCl fromWax Matrix

Abstract

The very water soluble drug, trifluoperazine HCl was prepared as sustained release carnauba wax matrix tablets using direct compression method.
Different amounts of carnauba wax as matrix substance was used to show its effect on drug release. Also sintering as new technique was used in order to
retard the drug release from carnauba wax matrix tablets; the granules before compression or the tablets after compression were exposed to 90°C or 120°C for 3 or 5 minutes. Microwave is another technique which was used to prolong the drug release from carnauba wax matrix tablets. The granules before compression or the tablets after compression were exposed to microwave irradiation at 600 watt for 3 or 5 minutes.
The results revealed that the release of drug decreased significantly (p<0.05) when the when the amount of carnauba wax was increased. On the other hand, sintering of granules or tablets, exhibited a significant (p< 0.05) drug release retardation when the temperature was increased from 90° C to 120° C.
Furthermore, non significant differences (p> 0.05) in drug release was shown at different time of sintering for 90°C or 120°C. The microwave irradiation
directly on tablets had a significant (p< 0.05) retarding effect on drug release, particularly for tablet exposed to 5 minutes since the drug release prolonged
from 3hr for unmicroaved tablet to 6 hr for microwaved one.