Synthesis and characterization of benzylidene- [1,3,4]thaidiazol -2-yl-amine

Abstract

This study was designed to synthesize chemically 2-aminothiadiazole derivatives and conversion to Schiff’s base. The principle synthesis of these compounds was to involve three steps:
First : by thermal cyclization of thiosemicarbazied with carbon disulfide in the presence of potassium hydroxide dissolved in anhydrous ethanol to yield 2-amino-5- mercapto-1,3,4-thiadiazole.
Second : by thermal cyclization of thiosemicarbazied with substituted carboxylic acid and sulphuric acid, to yield 2-amino-5-R-1,3,4-thiadiazole.
Third : Schiff’s base formation by reflux of aromatic aldehyde with 2-amino-5-R-1,3,4-thiadiazole in the presence of ethanol.
The chemical structures of all prepared compounds were confirmed by spectral data (UV-visible and IR spectroscopy) tables (1, 2, and 3).