Comparative Study between the Glycemic Control of Human Insulin and Insulin analogue In Sample of Iraqi Type 1 Diabetic Children and Adolescents

Authors

  • Noor Wafaa Hashim *Department of Clinical Pharmacy/ College of Pharmacy /Mustansiriyah University
  • Kadhim Ali Ali *Department of Clinical Pharmacy/ College of Pharmacy /Mustansiriyah University
  • Abbas Mahdi Rahmah **National Center for Diabetes Treatment and Research/ Mustansiriyah University

DOI:

https://doi.org/10.32947/ajps.v18i2.482

Keywords:

Insulin analogue, Conventional Human insulin, Glycemic control

Abstract

Insulin analogue introduced to offer insulin replacement therapy mimic to normal human physiology. The aim of this study is to compare between the glycemic control of insulin analogue and conventional human insulin in a sample of type 1 diabetic Iraqi children and adolescents. Forty type 1 diabetic Iraqi children and adolescents age between (6-18) years enrolled in this study and divided into two groups. Group 1 contains 20 patients switched from human insulin to insulin analogue. Group 2 contain 20 patients continued with conventional human insulin. The results showed that both therapies reduced fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c %) but insulin analogue treated group had highly significant reduction. Both therapies did not affect on blood urea nitrogen and serum creatinine. Human insulin reduced triglyceride (TG) and very low-density lipoprotein (VLDL) significantly. The parameters measures at baseline and after three months of treatments. In conclusion insulin analogue is superior over conventional human insulin in reducing glycemic indices in a sample of type 1 diabetic Iraqi children and adolescents.

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Published

2018-12-01

How to Cite

Hashim, N. W., Ali, K. A., & Rahmah, A. M. (2018). Comparative Study between the Glycemic Control of Human Insulin and Insulin analogue In Sample of Iraqi Type 1 Diabetic Children and Adolescents. Al Mustansiriyah Journal of Pharmaceutical Sciences, 18(2), 100–104. https://doi.org/10.32947/ajps.v18i2.482