Design and Synthesis of new Naproxen Analogues as Potential Anti-inflammatory Agents

Noor H. Nasser; Nethal H. Hammud; Samer A. Hasan; Abbas Hamid Abdalsadh; Ahmed kareem Hussein

doi:10.32947/ajps.v17i1.61

Design and Synthesis of new Naproxen Analogues as Potential Anti-inflammatory Agents

Authors

Noor H. Nasser Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kufa, Najaf, Iraq.
Nethal H. Hammud Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kufa, Najaf, Iraq.
Samer A. Hasan Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kufa, Najaf, Iraq.
Abbas Hamid Abdalsadh Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kufa, Najaf, Iraq.
Ahmed kareem Hussein Department of Pharmaceutical Chemistry, College of Pharmacy, University of Kufa, Najaf, Iraq.

DOI:

https://doi.org/10.32947/ajps.v17i1.61

Keywords:

amine derivatives, anti-inflammatory Agents, derivatives of naproxen

Abstract

4-aminobenzenesulfonamide derivatives were linked to α-carbon of naproxen a non-selective non-steroidal anti-inflammatory drug (NSAID) to increase its size, so; increase its selectivity toward COX-2 enzyme, rather than COX-1 enzyme, that lead to reduce gastrointestinal side effects of this drug.
The chemical structures of the synthesized compounds and their intermediates were confirmed and characterized using elemental microanalysis (CHN), FTIR, and other physicochemical properties like melting points, Rf values.

Downloads

Published

2018-03-13

How to Cite

Nasser, N. H., Hammud, N. H., Hasan, S. A., Abdalsadh, A. H., & Hussein, A. kareem. (2018). Design and Synthesis of new Naproxen Analogues as Potential Anti-inflammatory Agents. Al Mustansiriyah Journal of Pharmaceutical Sciences, 17(1), 9. https://doi.org/10.32947/ajps.v17i1.61

Issue

Vol. 17 No. 1 (2017): Volume 17, Issue 1. 2017

Section

Articles

License

AJPS is an open-access journal that all contents are free of charge. Articles of this journal are licensed under the terms of the Creative Commons Attribution International Public License CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/legalcode) that licensees are unrestrictly allowed to search, download, share, distribute, print, or link to the full texts of the articles, crawl them for indexing and reproduce any medium of the articles provided that they give the author(s) proper credits (citation). The journal allows the author(s) to retain the copyright of their published article.

Creative Commons-Attribution (BY)