Nigella Sativa Oil for Oral Mucositis


  • Hazha Abdullah MohammedAmeen Department of Medicine, College of Medicine, University of Sulaimani. Kurdistan Region, Iraq
  • Mohammed Omer Mohammed Department of Medicine, College of Medicine, University of Sulaimani. Kurdistan Region, Iraq
  • Rebaz HamaGareb Ali Department of Pharmaceutics, College of Pharmacy, University of Sulaimani, Kurdistan Region, Iraq
  • Khadija Muhamed Ahmed Department of Oral Pathology, College of Dentistry, University of Sulaimani, Kurdistan Region, Iraq
  • Saad Abdulrahman Hussain Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Rafidain University College, Baghdad, Iraq



Nigella sativa; oral mucositis; chemoradiation; head and neck cancer


Oral mucositis (OM) is common treatment-induced toxicity in patients receiving chemoradiation for head and neck cancer (HNC). The present study aims to evaluate the efficacy and safety of Nigella sativa (NS) oil in chemoradiation-induced OM of HNC patients. From


January 2017 to May 2018, 40 patients with HNC were randomly allocated into two groups each of 20 patients. The first group received NS oil mouthwash five times daily, while the second group received the routinely followed protocol (magic mouthwash) and served as a control. All patients received radiotherapy (RT) (60-70 Gy) in 30-35 fractions over 6-7 weeks with or without chemotherapy. Patients were evaluated weekly to estimate the onset and severity of OM and the patient’s reported outcomes (pain, swallowing, and functional score). The majority of patients (70%) were men. The commonest primary tumor locations were the larynx (47.5), and pharynx (22.5%) mostly classified as stages III or IV. NS oil significantly reduces the RTOG of mucositis in the last 3 weeks of RT and improves the reported outcomes (pain and swallowing) during the next 6 weeks of RT compared with controls. The majority of patients in the NS group ingested either normal or soft food especially at the end of RT. In conclusion, NS oil decreases the duration and severity of OM with better patient-reported outcome and pain control compared with the routine treatment. NS oil can be considered as a feasible and affordable option for chemoradiation-induced OM in HNC patients.




How to Cite

MohammedAmeen, H. A., Mohammed, M. O., Ali, R. H., Ahmed, K. M., & Hussain, S. A. (2019). Nigella Sativa Oil for Oral Mucositis. Al Mustansiriyah Journal of Pharmaceutical Sciences, 19(3), 54–67.