Effect of Vitamin D supplement on Gingivitis and Salivary Parameters in Patients with Vitamin D deficiency

Abstract

Background : Vitamin D, play a role in maintain oral health through it is effect on bone and mineral metabolism as well as it is effect on innate immunity. In addition most recent studies confirmed it is antimicrobial and anti-inflammatory effect.
Aims: To evaluate the effect of Vitamin D supplement on gingival index, salivary Immnoglobuline A ( SIgA) secretion rate,salivary flow rate( SFR) and salivary PH. As antimicrobial and anti-inflmmtory effect.
Subjects and methods: Out of 132 patients, 28 with vit.D deficiency and gingivitis currently on initial supplement with vit.D was chosen to participate in this study. Patients who take the medication regularly throughout the study were considered as patients group and who did not take the medication due to any reason were assigned as control group. Gingival index ,Salivary Immunoglobuline A (SIgA),Salivary flow rate (SFR) and salivary PH were assessed pre and post administration of vitamin D.
Results:- The result of current study revealed that the gingival index was significantly reduced post supplement of vit.D in patients who were taken the medication regularly (pre=2.7, post 1.8, p=0.01) while nonsignificant difference was seen in control group (pre=2.9, post 2.6, p=0.6).The salivary IgA, SFR and salivary PH was significantly increased(p≤0.05) after supplement of vit.D with patients who were taken the medication regularly (pre=434.3, post=687.7)(pre=0.9, post=1.8)( pre=6.7, post=7.1) respectively while nonsignificant difference(p≥0.05) was reported with control group (pre=424.3, post=467.7)9pre=0.8, post=1.1)(pre=6.5, post=6.8) respectively.
Conclusion :- According to results inthis study, we conclude that, the using of Vitamin D supplement lead to asignificant anti-inflammatory effect and also and also patient with gingivitis to be screened for Vit. D deficiency.