An overview of emulgels for topical application

Authors

  • Mina J. Jabbar Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad- Iraq
  • Wedad K. Ali Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad- Iraq

DOI:

https://doi.org/10.32947/ajps.v23i3.1043

Keywords:

Emulgel, Extrudability, Formulation, Spreadability

Abstract

In recent years, gels have been preferentially used for cosmetics and topical pharmaceutical preparations due to their favorable characteristics, such as being greaseless, readily spreadable and easily removable. However, one

obstacle that faced it was the inability to enclose hydrophobic compounds. Therefore, a novel approach was developed to circumvent this limitation by mixing the gel with an emulsion, which led to creation of a new topical drug delivery system known as emulgel. Emulgel preserves all favorable features of gel and provides also dual release for drug, thus can be utilized effectively in controlling release and absorption of medication after topical application. Emulgel preparation requires coherent steps, this includes preparation of emulsion and gel and determining their mixing ratio. Finally, the prepared emulgels should be evaluated to ensure their suitability and efficacy for the topical application.

References

- Mohammed, M. M.; Hamadi, S. A.; Aljaf, A. N. Formulation of melatonin as a cream and studying the release, diffusion, and stability of the cream. Al Mustansiriyah Journal of Pharmac-eutical Sciences 2009. 6 (1): 43-55. DOI: https://doi.org/10.32947/ajps.v6i1.357

- Buhse, L.; Kolinski, R.; Westenberger, B.; Wokovich, A.; Spencer, J.; Chen, C. W.; Turujman, S.; Gautam-Basak, M.; Kang, G. J.; Kibbe, A. Topical drug classification. International journal of pharmaceutics 2005. 295 (1-2): 101-112. DOI: https://doi.org/10.1016/j.ijpharm.2005.01.032

- Dhawas, V.; Dhabarde, D.; Patil, S. Emulgel: A comprehensive review for novel topical drug delivery system. International Journal of Recent Scientific Research 2020. 11 (4):38134-38138.

- Kumar, D.; Rajni, R. S.; Rani, S.; Kumari, R. Formulation And Evaluation Of Emulgel Of An Antifungal Drug For Topical Drug Delivery. Journal of Pharmaceutical Negative Results 2023: 4087-4100. DOI: https://doi.org/10.47750/pnr.2022.13.S08.517

- Iqbal, M. A.; Md, S.; Sahni, J. K.; Baboota, S.; Dang, S.; Ali, J. Nanostructured lipid carriers system: recent advances in drug delivery. Journal of drug targeting 2012. 20 (10): 813-830. DOI: https://doi.org/10.3109/1061186X.2012.716845

- Bhowmik, D. Recent advances in novel topical drug delivery system. The Pharma Innovation 2012. 1 (9).

- Gannu, R.; Palem, C. R.; Yamsani, V. V.; Yamsani, S. K.; Yamsani, M. R. Enhanced bioavailability of lacidipine via microemulsion based transdermal gels: formulation optimization, ex vivo and in vivo characterization. International journal of pharmaceutics 2010. 388 (1-2): 231-241. DOI: https://doi.org/10.1016/j.ijpharm.2009.12.050

- Verma, P.; Thakur, A.; Deshmukh, K.; Jha, A.; Verma, S. Routes of drug administration. International Journal of Pharmaceutical Studies and Research 2010. 1 (1): 54-59.

- Sahle, F. F.; Gebre-Mariam, T.; Dobner, B.; Wohlrab, J.; Neubert, R. H. Skin diseases associated with the depletion of stratum corneum lipids and stratum corneum lipid substitution therapy. Skin pharmacology and physiology 2015. 28 (1), 42-55. DOI: https://doi.org/10.1159/000360009

- Sabri, H. S.; Alia, W. K.; Abdullahb, B. H.; Al-Anic, W. Formulation design and evaluation of anti-microbial activity of emulgel containing essential oil of myrtus communis L. Inter J Pharm Sci Rev Res 2016. 40: 271-277.

- Abdo, J. M.; Sopko, N. A.; Milner, S. M. The applied anatomy of human skin: A model for regeneration. Wound Medicine 2020. 28. 100179. DOI: https://doi.org/10.1016/j.wndm.2020.100179

- Panwar, A.; Upadhyay, N.; Bairagi, M.; Gujar, S.; Darwhekar, G.; Jain, D. Emulgel: a review. Asian J Pharm Life Sci 2011. 2231. 4423.

- Alkilani, A. Z.; Nasereddin, J.; Hamed, R.; Nimrawi, S.; Hussein, G.; Abo-Zour, H.; Donnelly, R. F. Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems. Pharmaceutics 2022. 14 (6). 1152. DOI: https://doi.org/10.3390/pharmaceutics14061152

- Agarwal, S.; Krishnamurthy, K. Histology, skin. 2019.

- Pappalardo, A.; Cespedes, A.; Vu, H. L.; Abaci, H. E. Advances in skin-on-a-chip and skin tissue engineering. In Principles of Human Organs-on-Chips, Elsevier. 2023.pp :123-166. DOI: https://doi.org/10.1016/B978-0-12-823536-2.00005-5

- Vestita, M.; Tedeschi, P.; Bonamonte, D. Anatomy and Physiology of the Skin. In Textbook of Plastic and Reconstructive Surgery, Springer, 2022; pp :3-13. DOI: https://doi.org/10.1007/978-3-030-82335-1_1

- Ranjan, A.; Duryodhan, V. S.; Patil, N. D. A comparative study of passive drug diffusion through human skin via intercellular and sweat duct route: effect of aging. 2023. DOI: https://doi.org/10.21203/rs.3.rs-2392885/v1

- Wortsman, X.; Ferreira-Wortsman, C.; Corredoira, Y.; Pizarro, K. Comprehensive Ultrasonographic Anatomy of the Normal Skin, Nail, Hair, and Adjacent Structures. Textbook of Dermatologic Ultrasound 2022: 89-100. DOI: https://doi.org/10.1007/978-3-031-08736-3_5

- Kolimi, P.; Narala, S.; Youssef, A. A. A.; Nyavanandi, D.; Dudhipala, N. A systemic review on development of mesoporous nanoparticles as a vehicle for transdermal drug delivery. Nanotheranostics 2023. 7 (1): 70-89. DOI: https://doi.org/10.7150/ntno.77395

- Redkar, M. R.; Patil, S. V.; Rukari, T. G. Emulgel: A modern tool for topical drug delivery. World Journal of Pharmaceutical Research 2019. 8 (4): 586-597.

- Maqbool, A.; Mishra, M. K.; Pathak, S.; Kesharwani, A.; Kesharwani, A. Semisolid dosage forms manufacturing: Tools, critical process parameters, strategies, optimization, and recent advances. Ind. Am. J. Pharm. Res 2017.7: 882-893.

- Garg, T.; Rath, G.; Goyal, A. K. Comprehensive review on additives of topical dosage forms for drug delivery. Drug delivery 2015. 22 (8): 969-987. DOI: https://doi.org/10.3109/10717544.2013.879355

- Kumar, M. S. AN OVERVIEW OF EXCIPIENTS USED IN SEMISOLID PREPARATION. 2022.

- Arora, R.; Khan, R.; Ojha, A.; Chopra, H.; Upadhyaya, K. Formulation and characterization of terbinafine emulgel for superficial fungal infections. Res. J. Pharm. Technol 2018. 11:5029-5036. DOI: https://doi.org/10.5958/0974-360X.2018.00917.4

- Chauhan, S. B. Formulation and Evaluation of Emulgel for the treatment of Acne. EVALUATION 2020. 100 (100). 100.

- Lakshmi, S. S.; Divya, R.; Rao, S. Y.; Kumari, K. P.; Deepthi, K. Emulgel-novel trend in topical drug delivery system-review article. Research Journal of Pharmacy and Technology 2021. 14 (5): 2903-2906. DOI: https://doi.org/10.52711/0974-360X.2021.00509

- Abdallah, M. H.; Elghamry, H. A.; Khalifa, N. E.; Khojali, W. M.; Khafagy, E.-S.; Lila, A. S. A.; El-Horany, H. E.-S.; El-Housiny, S. Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity. Gels 2022. 8 (11). 737. DOI: https://doi.org/10.3390/gels8110737

- Zou, Y.; Zhong, J.; Pan, R.; Wan, Z.; Guo, J.; Wang, J.; Yin, S.; Yang, X. Zein/tannic acid complex nanoparticles‐stabilised emulsion as a novel delivery system for controlled release of curcumin. International Journal of Food Science & Technology 2017. 52 (5): 1221-1228. DOI: https://doi.org/10.1111/ijfs.13380

- Redkar, M. R.; Hasabe, P. S.; Jadhav, S. T.; Mane, P. S.; Kare, D. J. Review on optimization base emulgel formulation. Asian Journal of Pharmacy and Technology 2019. 9 (3):228-237. DOI: https://doi.org/10.5958/2231-5713.2019.00038.2

- Campanholi, K. d. S. S.; Junior, R. C. d. S.; Jaski, J. M.; Silva, J. B. d.; Oliveira, M. C. d.; Santos, R. S. d.; Pozza, M. S. d. S.; Castro-Hoshino, L. V. d.; Baesso, M. L.; Cardozo-Filho, L. Thermo and Photoresponsive Emulgel Loaded with Copaifera reticulata Ducke and Chlorophylls: Rheological, Mechanical, Photodyna-mic and Drug Delivery Properties in Human Skin. Pharmaceutics 2022. 14 (12). 2798. DOI: https://doi.org/10.3390/pharmaceutics14122798

- Dessai, P.; Mhaskar, G. M. Formulation and Evaluation of Ginger officinale Emulgel. Research Journal of Pharmacy and Technology 2019. 12 (4):1559-1565. DOI: https://doi.org/10.5958/0974-360X.2019.00258.0

- Vishwakarma, G.; Panwar, A. S. Review on emulgel: A novel technique for drug targeting.

- Khunt, D. M.; Mishra, A. D.; Shah, D. R. Formulation design & development of piroxicam emulgel. Int J PharmTech Res 2012. 4 (3):1332-1334.

- Shelke, O.; Sharma, M. Development of sustained release hydrophobic emulgel for oral care. Journal of Drug Delivery and Therapeutics 2019.9 (3): 447-454.

- Hafiz, Z.; Gul, S. Emulgel as Remarkable Drug Delivery System for Topical Preparations: Formulation Development of Emulgel & Quality Control Testing of Chloramphenicol Palmitate. Current Trends in Biotechnology & Pharmacy 2020.

- Vanpariya, F.; Shiroya, M.; Malaviya, M. Emulgel: A Review. International Journal of Science and Research (IJSR) 2021. 10. 847.

- Rowe, R. C.; Sheskey, P.; Quinn, M. Handbook of pharmaceutical excipie-nts; Libros Digitales-Pharm-aceutical Press. 2009.

- VISHWAKARMA, G.; PANWAR, A. S. EMULGEL EMERGENT SYSTEMS: AT A GLANCE FOR TOPICAL DRUG DELIVERY. Asian J Pharm Clin Res 2022. 15 (3):8-14. DOI: https://doi.org/10.22159/ajpcr.2022.v15i3.43876

- Joshi, V.; Kumar, K.; Khairya, D.; Teotia, D. EMULGEL AS A NOVEL DRUG DELIVERY SYSTEM: A COMPREHENSIVE REVIEW. Inter-national Journal of Indigenous Herbs and Drugs 2022: 94-98. DOI: https://doi.org/10.46956/ijihd.v7i5.354

- Kute, S.; Saudagar, R. Emulsified gel A Novel approach for delivery of hydrophobic drugs: An overview. Journal of Advanced Pharmacy Education & Research Oct-Dec 2013. 3 (4).

- Yadav, R.; Pandey, N. K.; Kukkar, R.; Dutta, D.; Avasthi, P.; Rana, M.; Modgil, S. Emulgel A Reliable System for Topical Delivery of Lipophilic Drugs in Present Scenario. Research Journal of Pharmacy and Technology 2022.15 (6): 2845-2848. DOI: https://doi.org/10.52711/0974-360X.2022.00475

- Singh, S.; Singh, I. Evolving Implementation of Emulgel as a Topical Drug Delivery System: A Systematic Review. Current Research in Pharmaceutical Sciences 2022: 121-131. DOI: https://doi.org/10.24092/CRPS.2022.120301

- Kegade, P.; Sawant, R.; Parkar, S.; Gade, A. Emulgel: In treatment of periodontitis. World Journal of Advance Healthcare Research 2020. 4 (5): 71-75.

- Mishra, A.; Mishra, A.; Chattopadhyay, P. Assessment of in vitro sun protection factor of Calendula officinalis L.(asteraceae) essential oil formulation. Journal of Young Pharmacists 2012. 4 (1): 17-21. DOI: https://doi.org/10.4103/0975-1483.93575

- Rana, N.; Singh, V.; Ali, M. Formulation and Characterization of Ginger oil loaded Polyherbal Emulgels having extracts of Nardostachys jatamansi, Androgra-phis paniculata and Celaestrus paniculatus. Research Journal of Pharmacy and Technology 2020. 13 (9): 4077-4083. DOI: https://doi.org/10.5958/0974-360X.2020.00720.9

- Ali, M. H. M.; Ali, W. K. Preparation and Evaluation of Emulgel as Topical Drug Delivery for Nimesulide by Using Conventional Emulsion. Al Mustansiriyah Journal of Pharmaceut-ical Sciences 2019. 19 (4):16-26. DOI: https://doi.org/10.32947/ajps.v19i4.629

- Khan, J.; Norfarhani, S.; Sahu, R. K.; Ruhi, S.; Kaleemullah, M.; Al-Dhalli, S.; Rasny, M.; Budiasih, S.; Baber, S.; Ng, C. H. Development and Evaluation of topical Emulgel of Aspirin using different Polymeric Bases. Research Journal of Pharmacy and Technology 2020. 13 (12): 6300-6304. DOI: https://doi.org/10.5958/0974-360X.2020.01096.3

- Chandel, M.; Sharma, C.; Kashyap, V. Topical delivery of clarithromycin emulgel with biocompatible polymers. In AIP Conference Proceedings, 2023; AIP Publishing LLC: Vol. 2558: p 020081. DOI: https://doi.org/10.1063/5.0137528

- Jyothi, V.; Pullemla, M.; Nafiroona, S.; Pujari, G.; Purama, R. Formulation and evaluation of curcumin emulgel for topical delivery. Journal of Pharmacognosy and Phytochemistry 2022. 11 (6): 33-41. DOI: https://doi.org/10.22271/phyto.2022.v11.i6a.14522

- Saeed, A. M.; Alaayedi, M.; Alhendawi, Z. M.; Hammoodi, I. D. EMULGEL AS PHARMACEU-TICAL FORMULATION: A REVIEW. kerbala journal of pharmaceutical sciences 2023. 1 (21).

Downloads

Published

2023-07-20

How to Cite

Mina J. Jabbar, & Wedad K. Ali. (2023). An overview of emulgels for topical application. Al Mustansiriyah Journal of Pharmaceutical Sciences, 23(3), 263–272. https://doi.org/10.32947/ajps.v23i3.1043