Assessment of Factors Affecting Therapeutic Response of the DPP-4 Inhibitor Sitagliptin in A Sample of Iraqi Type 2 Diabetic Patients

Ahmad Nazar Jawad; Kadhim Ali Kadhim; Qusay Baqer Alzajaji; Haider Al-Neshmi

doi:10.32947/ajps.v24i3.1082

Authors

Ahmad Nazar Jawad Department of Clinical Pharmacy, College of Pharmacy, Mustansiriyah University
Kadhim Ali Kadhim Department of Clinical Pharmacy, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq
Qusay Baqer Alzajaji Alhassan Metabolism, Endocrine and Diabetes center (HMEDC), Karbala, Iraq
Haider Al-Neshmi Griffith Base Hospital, NSW, Australia

DOI:

https://doi.org/10.32947/ajps.v24i3.1082

Keywords:

Type 2 diabetes, DPP-4 inhibitors, Sitagliptin

Abstract

Background: Type 2 diabetes is a complex and diverse disease, and the response to dipeptidyl peptidase-4 inhibitors may exhibit substantial variability between individuals. Several variables may play a role in variances in individual responses to treatment.

Objective: The purpose of the research was to assess the degree to which Iraqi patients with type 2 diabetes responded to sitagliptin and to investigate the factors that contribute to sitagliptin's overall efficacy.

Patients and methods: Eighty patients with type 2 diabetes who were using sitagliptin (100 mg per day) were included in this observational, cross-sectional study. Sociodemographic and patient clinical data were collected. Glycated hemoglobin (HbA1c), lipid profile parameters, and C-reactive protein were measured.

Results: The response rate to sitagliptin was 43.8%. Smokers and hypertensive patients, in addition to those not on diet, had higher HbA1c levels with nearly significant p values than non-smokers, normotensive patients, and those on diet, respectively. Poor response patients had higher levels of total cholesterol and triglycerides.

Conclusions: Possible variables that may have influenced the response to sitagliptin include smoking, hypertension, and an unhealthy diet. Furthermore, elevated levels of triglycerides may serve as an indicator of poor response.

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