Synthesis and Enzyme Hydrolysis Study of Acyloxyalkyl Carbamates as New Prodrugs for Amines

Main Article Content

Israa Abad Alrasol Mohamed Sadeq
Ali Rasool Mahmood Albakaa
Mohammed Al-Ameedee
Enageh A. A. Abdalgader

Abstract

In this review, we examined studies through 2023 with particular attention to the cases listed below. by investigate the potential of acyloxyalkyl carbamates for the amine-containing drug in order to overcome problems associated with medication transport and pharmacological activity of these drugs by improving drug delivery and penetration for amine drugs.


This review explores how the esterase enzymes can generate effective parent drugs to give pharmacological action.


The findings focus on two main concepts.  The first is activating enzymes and targeting their effects. The second concept focuses on creating pro-moieties that can achieve the intended outcome efficiently and how selecting the appropriate pro-moieties is crucial for creating stable compounds that do not produce any toxic byproducts. The review highlights the importance of enhancing drug solubility and permeability, particularly for amino-group prodrugs.

Article Details

Section

Reviews

How to Cite

Synthesis and Enzyme Hydrolysis Study of Acyloxyalkyl Carbamates as New Prodrugs for Amines. (2025). Al Mustansiriyah Journal of Pharmaceutical Sciences, 25(4), 493-500. https://doi.org/10.32947/ajps.v25i4.1155

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