Investigating the effect of hesperidin on atorvastatin-related liver toxicity: histopathological investigation
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Abstract
Background: liver-related side effects can occur with numerous medications, with effects ranging from a mild effect to death. While statins in general, especially atorvastatin, are not usually associated with liver damage, reports recently have been suggesting otherwise.
Objective: this study investigates the effects of various doses of hesperidin against hepatotoxicity caused by atorvastatin in rat model.
Method: Thirty apparently healthy male Wister rats were randomly and equally divided into five groups, each group containing six rats, each group was subjected to certain dose of medication for the entire time of the experiment that lasted for twenty days.
Results: atorvastatin caused numerous liver related toxicity while hesperidin demonstrated dose related hepatoprotective effects.
Conclusion: the characteristic protective features of hesperidin, most likely as an antioxidant, is able to provide protection against atorvastatin hepatotoxicity, however this protective effect is directly affected by the right dose.
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