Evaluationoof0theoRole0ofoGabapentin0and/oroOmega-30in0Uremic Pruritusofor0PatientsoUndergoing0Hemodialysis0

Sinan Forat Hussein; Kadhim Ali Kadhim; Ali Jassim Al_Sultani; Saad Abdulrahman Hussain

doi:10.32947/ajps.v17i2.157

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Published: 2017-12-01

DOI: https://doi.org/10.32947/ajps.v17i2.157

Keywords:

Gabapentin, Omega-3, Uremic Pruritus, Hemodialysis

Sinan Forat Hussein

Babil Directorate of Health, Babil, Iraq.

Kadhim Ali Kadhim

Department of Clinical Pharmacy ,College of Pharmacy, University of Mustansiriyah.

Ali Jassim Al_Sultani

Babil Directorate of Health, Babil, Iraq.

Saad Abdulrahman Hussain

Faculty of Pharmacy, Alrafidain University College, Baghdad, Iraq

Abstract

Uremicopruritus,0isochronic0itchingothat0occursoin0patientsowith0advancedoor0 end-stage renal0disease.oIt0isoone0ofocommon0symptomsoinopatients00with00end-stage renal0 diseaseowith0approximatelyo60–90%0ofopatients0on0hemodialysis(HD) suffering0fromothis0problem. This study wasodesigned0to evaluate theoefficacy0and safety of prescribing Gabapentinoand0Omega-3 in combination or aloneofor0relieving uremicopruritus0in Iraqi patients undergoing0hemodialysis. The resultsoshowed0that all the threeoinvolved0regimens0(gabapentin, omega-3,0and the combinationoof0both drugs) had0significantly reduced the pruritus score. Furthermore,0theocombination0was significantlyosuperior0tooother0regimens in reducingopruritus 0score, owhile0no0significant effect0wasoobserved0by oallothe regimensoon0interleukin-6oor0on parathyroid hormone serum0levels.In Conclusion Gabapentin0100mgoplus01000mg0omega-30based fishooil capsules containing 120mg0DHA and0180mg0EPA isosuperior0to each drug alone0in reducing pruritus scoreoin0a0sample0of Iraqi0patients.

Issue

Vol. 17 No. 2 (2017): Volume 17, Issue 2. 2017

Section

Articles

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How to Cite

Evaluationoof0theoRole0ofoGabapentin0and/oroOmega-30in0Uremic Pruritusofor0PatientsoUndergoing0Hemodialysis0. (2017). Al Mustansiriyah Journal of Pharmaceutical Sciences, 17(2), 123-131. https://doi.org/10.32947/ajps.v17i2.157