Effect of Vitamin D, Metformin on Metabolic Syndrome in Polycystic Ovarian Syndrome Patient

Abstract

Polycystic ovary (PCO) is the most common hormonal disturbance disease that characteristic by anovulation, oligo-ovulation and increase androgen male hormone and presence small ulcers in ovary.

This study aims to find the effects of vitamin D and Metformin on FBS, Insulin, Cholesterol, HDL, LDL, TG and VLDL for Patients Receiving them.

Two sets were used,  the first set (G1)  includes 14 patients aged range between 18 to 30 years old, which divided into two classes, the first class before treatment referred as (G1-A) and the second class after received vitamin D alone 4001.U the dose was a once daily for about 3 months referred to as (G1-B). Similarly, the second set (G2)also divided into two classes, the first class includes 14 patients their aged ranged between 19 to 30  years old before treatment referred to as (G2-A) and the second class after received (500 mg) metformin three time daily) for about 3 months to as (G2-B).

Results showed that there are significant pre and post treatment mean difference for fasting blood sugar, insulin resistance, cholesterol, HDL, LDL, TG,VLDL for patient that receiving vitamin D alone; so the study shows significant effect of vitamin D on fasting blood sugar and insulin resistance level. In second group that taken metformin alone, also there are significant pre and post treatment mean difference for fasting blood sugar, insulin resistance, cholesterol, HDL, LDL, TG and VLDL. Metformin reduced hyperglycemia primarily as a result of reducing glucose production by the liver (hepatic gluconeogenesis) and the metformin significantly decrease in serum insulin resistance, whereas metformin appear no significant effect on testosterone level.