Preparation of Polyvinylpyrrolidinone With Paracetamol as Drug Polymer
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Abstract
The prodrug polymer was prepared according to ring opening of polyvinyl pyrrollidinone with nuecleophilic attack of hydroxyl group of paracetamol.
The new colorless drug polymer was formed with 92% conversion percentage with intrinsic viscosity was equal to (0.61dl/g). The drug polymer was
characterized and identified by1H-NMR, IR and UV. Spectroscopy. Controlled released rates were studied in acidic and basic medium at 30 0C and 40 0C.
Rate of hydrolysis of paracetamolate ester acts as base > acid, and the rate of release, depends on temperature and pH values. The results show higher hydrolysis at higher temperature as well as higher pH value.
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How to Cite
Preparation of Polyvinylpyrrolidinone With Paracetamol as Drug Polymer. (2012). Al Mustansiriyah Journal of Pharmaceutical Sciences, 11(1), 177-185. https://doi.org/10.32947/ajps.v11i1.251
