Some Variable Affecting Formulationof Tinidazole Mucoadhesive Oral Gel

Abstract

Tinidazole (TZ) is an antibacterial drug used for treatment of periodentitis.More benefit may be obtained by the application of a localized oral drug delivery system consist of mucoadhesive polymers which increase the contact time between the base and the oral tissue. Different gel formulations were prepared using the bioadhesive polymers carbomer 941, sodium caroxymethylcellulose (SCMC), and guar gum. The influence of polymer type and polymers blend in varying ratio on the viscosity, bioadhesive strength, swelling index and drug release were evaluated. SCMC based gel showed fastest release in comparison with carbomer and guar gum based gel. Using polymer blend of SCMC with either carbomer or guar gum resulted in a modification of both release and physical properties. The release of TZ was decreased with increasing amount of carbomer and guar gum and decreasing amount of SCMC. And increasing the viscosity of the gel formulations resulted in a retardation effect on the release of the drug. The study also showed that formulas containing carbomer exhibited maximum swelling values with lower release rates and best mucoadhesion.