Oral Jellies for Improving Oral Drug Delivery in Dysphagia

Authors

  • Zainab H. Mahdi Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq

DOI:

https://doi.org/10.32947/ajps.v20i3.765

Keywords:

: Bioavailability, Dysphagia, Gel forming polymers, Preservatives.

Abstract

For many years, oral solid dosage forms were the most preferred dosage forms for a wide range of population due to their safety, efficacy, stability, cheapness and ease of administration. Swallowing difficulties and bioavailability problems are the main disadvantages for this rout.

For this reason, researchers try to develop easier rout of administration such as orodispersible tablet, mucoadhesive, sublingual and oral jelly was developed in an attempt to overcome this restriction. The ultimate purpose for this research is to introduce opportunities of providing the oral jelly as a suitable alternative to the readily available solid dosage forms of the same medicament, representing by that easily swallowed dosage form with improved bioavailability

References

- Syed NH, Shahnila A, Hina J, Asma N, Kashif K, Muhammad MJ. Formulation and evaluation of taste masked doxycycline Hcl medicated jelly. Der Pharmacia Sinica. 2017. Vol. 8(2). Pp: 33-39.

- Doolaanea AA, Bahari A. Advantages of jelly over liquid formulations for pediatrics. J Formul Sci Bioavailab. 2017. Vol. 1(1). Pp: 1-2.

- Raja MM, Dhiren PS. Oral medicated jelly: A Recent advancement in formulation. Pharma Sci Monit. 2016. Vol. 7(2). Pp: 13-20.

- Zainab HM, Nidhal KM. New easily swallowed tablets with slippery coating for the antihypertensive drug valsartan. UK J Pharm Biosci. 2015. Vol. 3(5). Pp: 9-19.

- Zainab HM, Nidhal KM, Zahraa AA. Application of liquisolid technology to enhance the dissolution of cefixime from its oral capsules. Int J App Pharm. 2018. Vol. 10(5). Pp: 214-219.

- Beeram V. Formulation, development and evaluation of cefixime oral medicated jelly. Indian J Pharm Sci. 2010. Vol. 78(2). Pp: 68-73.

- Gananrajan G, Gurleen, K, Preeti K. Formulation and evaluation of montelukast sodium oral jelly for pediatrics. JETIR. 2018. Vol. 5(7). Pp: 448-460.

- Mckinley, M.; Oloughlin, V. D. Human Anatomy. USA: McGrow-Hill Publishing; 2006.

- Fox, S.I. Human Physiology. 8th ed. USA: McGrow-Hill Publishing; 2004.

- Seely; Stephens; and Tate. Anatomy and Physiology. 6th ed. USA: McGrow-Hill Publishing; 2004.

- Hammond, C. A.; and Goldstein, L. B. Cough and aspiration of food and liquids due to oral-pharyngeal dysphagia ACCP evidence-based clinical practice guidelines. Chest. 2006. Vol. 129(1). Pp: 154-168.

- Barrett, K. E.; Barman, S. M.; Boitano, S.; and Brooks H.L. Ganong's Review of Medical Physiology [Electronic Copy]. 23rd ed. USA: McGraw-Hill Publishing; 2010.

- Sperelakis, N.; and Banks, R. O. Essentials of Physiology. 2nd ed. London: Sperelakis N. and Banks R.O Publishing, 1996.

- Mechanisim of normal swallowing picture (Study blue) [Image on the internet]. 2012 [cited 2019 Mar 24]. Available from: https://classcon-nection.s3.amazonaws.com/844/flashcards/2475844/png/deglutition1355932101318.png.

- Sree, S.S. Dysphagia- a review. JPSR. 2014. Vol. 6(9). Pp: 302-304.

- Aslam, M.; and Vaezi, M.F. Dysphagia in the elderly. Gastroenterology & Hepatology. 2013. Vol. 9(12). Pp: 784-795.

- Taranum, R.; and Mittapally, S. Soft chewable drug delivery system: Oral medicated jelly and soft chew. J Drug Deliv Ther. 2018. Vol. 8(4). Pp: 65-72.

- Sarojini, S.; Anusha, K.; Maneesha, C.; Mufaquam, M. A.; Deepika, B.; and Krishna, R. Y. Oral medicated jellies - A Review. World J Pharm Res. 2018. Vol. 7(6). Pp: 352-365.

- CHMP. Reflection paper: formulations of choice for the paediatric population. EMEA. 2006.

- Sankar, V.; Hearnden, V.; Hull, K.; Juras, D. V.; Greenberg, M.; and Kerr, A. R. Atenolol gastrointestinal therapeutic system in screening of formulation variables. Drug Dev Ind Pharm. 1997. Vol. 23(1). Pp: 157-165.

- Mohammed, M.; Joshua, S. B.; Babur, Z. C.; Martin, J. S; and Dennis, D. A review on the taste masking of bitter APIs: hot-melt extrusion (HME) evaluation. Drug Dev Ind Pharm. 2014. 40(2). Pp: 145-156.

- Felipe, L. L.; Terry, B E.; Catherine, T.; and Mine, O. G. Formulation approaches to pediatric oral drug delivery: benefits and limitations of current platforms. Expert Opin. Drug Deliv. 2015. Vol. 12(11). Pp: 1-14.

- Smart, J. D. Lectin- mediated drug delivery in the oral cavity. Adv Drug Deliv Rev. 2004. Vol. 5(6). Pp: 481-489.

- Kalpana, N.; Shailendra, K. S.; and Mishra, D. N. Patent innovation in FDDFs. In: Vikas, A. S., editor. Current advances in drug delivery through fast dissolving/disintegrating dosage forms. UAE: Bentham Science Publisher; 2017. Pp: 119-166.

- Zhenguo, G.; Sohrab, R.; Junbo, G.; and Jingkang, W. Recent developments in the crystallization process: toward the pharmaceutical industry. Engineering. 2017. Vol. 3 (1). Pp: 343-353.

- Pfister, W. R.; and Ghosh, T. K. Intraoral delivery systems: An Overview, current status and future trends. In: Tabash, K. Ghosh and William, R. Pfister, editors. Drug delivery to the oral cavity: molecules to market. USA: CRC Press; 2005. Pp: 1-40.

- Mehta, R. M. Pharmaceutics II. 2nd ed. India: VallabhPrakashan; 2003.

- Chudamani, Y.; Shaffi, T.; and Raman, Y. A review: Recent advancement in formulation of oral medicated jelly. World J Pharm Pharm Sci. 2018. Vol. 7(7). Pp: 417-426.

- Gurleen, k.; and Gananarajan, G. A review article on oral jellies for pediatrics. Indo Am J Pharm Sci. 2018. Vol. 5(1). Pp: 444-452.

- Dixit, A. S.; Parthasarathi, K. K.; and Hosakote, G. S. Gels and jellies as a dosage form for dysphagia patients: a review. Curr Drug Ther. 2011. Vol. 6. Pp: 79-86.

- Cooper and Gun. Dispensing for pharmaceutics. 12th ed. Daraya Ganj New Delhi: CBS Publishers and Distributors; 2000.

- Raja, M. M.; and Dhiren, P. Oral medicated jelly: a recent advancement in formulation. Int J Pharm Pharm Sci. 2016. Vol. 7(2). Pp: 13-20.

- Wikipedia contributors. Preservative. Wikipedia, the Free Encyclopedia [online]. [Cited 2019 Dec12]. Available from URL: https://en.wikipedia.org/w/index.php?title=Preservative&oldid=845498444.

- Ninomiya, H.; Shimizu, T.; Dairaku, M.; Komagata, T.; and Misawa, M. inventors; Nichi-Iko Pharmaceutical Co Ltd Ohta Seiyaku Kk, assignee. Jellied medical composition for oral administration. US Patent 5,932,235. 1999 August 3.

- Gavaskar, B.; Kumar, V. S.; Guru, S.; and Rao, M. Y. Overview on fast dissolving films. Int J Pharm Pharm Sci. 2010. Vol. 2(3). Pp: 29-33.

- Renu; and Jyoti, D. Chewable tablets: a comprehensive review. Pharma Innovation. 2015. Vol. 4(5). Pp: 100-105.

- Debojyoti, B. Organoleptic agents: Adaptability, acceptability and palatability in formulations to make it lucrative. World J Pharm Res. 2015. Vol. (4). Pp: 1573-1586.

- Pramod, K. B.; Manoj, K. M.; Anupam, S. B.; and Vivek, K. Y. An updated review on colorants as the pharmaceutical excipients. IJPCBS. 2015. Vol. 5(4). Pp: 1004-1017.

- Salunke, T.; and Mayee, R. Formulation and evaluation of medicated jelly of bitter drugs. IJPI. 2013. Vol. 3(5). Pp: 1-14.

- Kanika, N.; Manoj, K. M.; and Garima, V. Formulation and evaluation of oral soft jelly containing glibenclamide. Indo Am J Pharm Sci. 2016. Vol. 3(10). Pp: 1276-1282.

- Harish, S. K.; Sheikalisha, A.; Chandra, S.; Suresh, R.; Sangeetha, S.; and Tamilselvan, A. Formulation and evaluation of oral medicated jellies of cyproheptadine hcl. IJAPS. 2018. Vol. 1(8). Pp: 7-41.

- Tushar, V. A.; Avish, D. M.; Mitesh, P. S.; Prasad, S. B.; and Kiran, B. E. Formulation, development and evaluation of albendazole oral jellies. Indo Am J Pharm Sci. 2016. Vol. 3(7). Pp: 706-712.

- Arun, R. R.; Jibcy, F. R.; and Jyoti, H. Formulation and evaluation of domperidone medicated jelly using solvent deposition method for solubility enhancement. RRJODFDP. 2017. Vol. 4(2). Pp: 40-53.

- Zahraa, M. K.; and Wedad, K. A. Utilization of natural polymer in the preparation of oral jelly of granisetron. AJPS. 2019. Vol. 19, No.2. Pp: 1-8.

- Natarajan, R.; and Prabhu, C. Formulation development and evaluation of tadalafil oral jelly compared with marketed product. Int J res pharm chem. 2014. Vol. 4(2). Pp: 479- 483.

- Chhajed, M. Formulation development and evaluation of unit moulded semisolid jelly for oral administration as a calcium supplement. World J Pharm Res. 2012. Vol. 1(3). Pp: 626-634.

- Patil, A. N.; Chaudhary, S.; and0 Shah, H. Formulation and evaluation of levocetrizie dihydrochloride soft gel for oral administration. IJPRBS. 2016. Vol. 5(2). Pp: 178-198.

- Zahraa, M. K.; and Wedad, K. A. Preparation and Evaluation of Granisetron Chewable Pediatric Oral Jelly. IJDDT. 2019. 39(3): 347-351.

- Melissa, R. C.; and Padmini, R. Design, development and evaluation of novel oral medicated jellies. Indo Am J Pharm Sci. 2017. Vol. 4 (6). Pp: 1746-1754.

- Gohel, M. C.; Parikh, R. K.; Nagori, S. A.; Shah, S. N.; and Dabhi, M. R. Preparation and evaluation of soft gellan gum gel containing paracetamol. Indian J Pharm Sci. 2009. Vol. 71(2). Pp: 120-124.

- Hassen, A. H.; and Shanmugam, S. Preparation and evaluation of a new gel formulation of paracetamol. J. Pharm. Res. 2009. Vol. 2(8). Pp: 1269-1271.

- Katakam, P.; Varanasi, M. S.; Hwisa, T. N.; Assaleh, H. F.; Adiki, K. S.; and Avula, R. P. Formulation development and evaluation of novel oral jellies of carbamazepine using pectin, guar gum, and gellan gum. Asian J. Pharm. 2014. Vol. 1(1). Pp: 241-249.

- Natarajan, R.; Prabhu, C.; and Rajendran, N. N. Formulation development and evaluation of tadalafil oral jelly comparative with marketed product. IJRPC. 2014. Vol. 4(2). Pp: 479-483.

- Mahendrakumar, D.; and Zankhana, S. Design and development of oral medicated jelly of palonosetron hydrochloride. PIJR. 2015. Vol. 4(6). Pp: 253-255.

- Javalgikar, A.; and Shinde, V. Formulation of clotrimazole ororetentive jelly. J. drug deliv. ther. 2016. Vol. 6(2). Pp: 21-25.

- Jadhav, S. B.; Bharkad, V. B.; Shinde, M. K.; Kadam, V. S.; and Katkam, P. Development and evaluation of oral medicated jelly of ondansetron hydrochloride. WJPPS. 2017. Vol. 6(9). Pp: 1536-1549.

- Ruheena, T.; and Sirisha, M. Formulation and evaluation of domperidone oral jelly. IJPBS. 2018. Vol. 8(4). Pp: 870-878.

- Prasanthi, N. L.; Nandini, P.; Manikiran, S. S.; and Ramarao, N. Design and development of herbal pediatric edible jelly for anthelmintic infections. J. Pharm. Sci. & Res. 2019. Vol. 11(6). Pp: 2417-2421.

- Kazuhiro, I. Alendronate sodium hydrate (oral jelly) for the treatment of osteoporosis: review of a novel, easy to swallow formulation. Clin Interv Aging. 2013. Vol. 1(1). Pp: 681-688.

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Published

2020-09-01