The effect of different concentrations of surface active agent on the absorption of sulphamethoxazole and trimethoprim from rabbit ileum

Authors

  • Manal khalid abdul ridha Department of pharmacotheraputics, Collage of pharmacy, Al – Mustansiriya University

DOI:

https://doi.org/10.32947/ajps.v5i1.372

Abstract

A combination of sulphamethoxazol SMX and trimethoprim TMP is widly used in the treatment of various systemic infections . This investigation was carried out to see the effect of increasing concentration of surface active agents ( SAA ) used in suspensions on the absorption of both drugs from isolated rabbit ileum . The study was carried out at PH 7.4 and at 37°C . The SAA chosen were tween 80, sodium laurylsulphate ( SLS ), polyethylene glycole ( PEG400 ), and PEG4000 at a concentrations of 0.1%w/v , 1%w/v, 2%w/v and 15% w/v (Note : 15% was chosen for the purpose of the investigation not as a concentration for formulation ). It was found that the absorption of both drugs decreased as a function of increasing the concentration of the different SAA.

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Published

2008-06-01

How to Cite

abdul ridha, M. khalid. (2008). The effect of different concentrations of surface active agent on the absorption of sulphamethoxazole and trimethoprim from rabbit ileum. Al Mustansiriyah Journal of Pharmaceutical Sciences, 5(1), 5–15. https://doi.org/10.32947/ajps.v5i1.372