Synthesis, spectroscopic characterization of new heterocycles based on sulfamethoxazole as potent antimicrobial agents

Abstract

A series of sulfamethoxazole derivatives attached to heterocyclic ring such as 1,2-diazepane (3), 1,3,4-oxadiazole (4), two pyrazoles (5,6), 1,2,4-triazine (7), 1,3,4-oxadiazine (8) and four novel 1,3-oxazepines (14-17)were designed and synthesized in this research. The structures of the newly prepared compounds were confirmedbased on a comprehensive characterization of spectral data by applied (infrared, proton and carbon nuclear magnetic resonance spectroscopy). Physicochemical properties also determined for each synthesized derivatives. The finallyprepared compounds were tested for their anti-bacterial and fungal activity invitro. Four types of pathogenic bacteria with two types of yeast similar to fungi were used in the evaluation. Each screened compounds showed perfect antimicrobial activity comparable with sulfamethoxazole used as parent drug