Synthesis, Antibacterial study and ADME Evaluation of Novel Isonicotinoyl Hydrazide Derivative Containing 1,3,4-Oxadiazole Moiety

Mazen Mohammed Jwaid; Karima Fadhil Ali; Mayada Hadi Abd-alwahab

doi:10.32947/ajps.v20i4.781

Authors

Mazen Mohammed Jwaid Department of Pharmacy, Baghdad College of Medical Science, Baghdad, Iraq
Karima Fadhil Ali College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq
Mayada Hadi Abd-alwahab College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq

DOI:

https://doi.org/10.32947/ajps.v20i4.781

Abstract

Novel derivative of isoniazid containing 1,3,4-oxadiazole pharmacophore has been synthesized. The chemical structure of the compound was characterized and confirmed by using FT-IR and ¹H-NMR spectroscopy.

The desired compound was tested against gram-positive and gram-negative bacteria using agar well-diffusion technique for their ability as antibacterial agent and showed good antibacterial activity against gram-negative bacteria and gram-positive bacteria. In addition, ADME evaluations were performed using Swiss ADME to predict if the synthesized compound can be given orally, the bioavailability, topological polar surface area, and drug-likeness. The result showed that all tested compounds absorbed orally and fulfilled the Lipinski rule.

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