Synthesizing, Studying Molecular Docking, Characterizing, and Preliminary Evaluating Anti-Bacterial Effects of Derivatives of Serotonin Contain Imidazolidine Ring

Authors

  • Marwa Abdullah Saleh AL-Dour health care sector, Salah Al-Deen Directorate of Health, Ministry of Health, 34007, Salah Al-Deen, Iraq AL-Dour health care sector, Salah Al-Deen Directorate of Health, Ministry of Health, 34007, Salah Al-Deen, Iraq
  • Karima Fadhil Ali Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, 10001, Baghdad, Iraq
  • Basma M. Abd Razik Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, 10001, Baghdad, Iraq

DOI:

https://doi.org/10.32947/ajps.v22i3.884

Keywords:

Serotonin; Imidazolidine; Molecular docking

Abstract

This study included synthesis of new serotonin derivatives in which imidazolidine rings are present in their structures. The final imidazolidine derivatives compounds were synthesized by reaction of synthesized

 

Schiff bases derivatives of serotonin with the glycine (NH2-CH2COOH) in presence of tetrahydrofuran (THF) as a solvent. The imidazolidine derivatives were identified by physical characteristics, FT-IR spectroscopy and 1H- NMR spectroscopy. Biological activities against two Gram negative (Klebsiella and E. coli) and two Gram positive (Streptococcus pyogenes and Staphylococcus aureus) bacteria were also distinguished. All the synthesized compounds III(a-d) exhibit moderate activities on four types of bacteria comparing with the activity of standard drug (Trimethoprim) but the highest activities of these compounds occur on Streptococcus pyogenes and their least activities occur on E. coli. The synthesized compounds were studied for the molecular docking to know the interaction and affinity of binding between them and bacteria

 

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Published

2022-10-24

How to Cite

Synthesizing, Studying Molecular Docking, Characterizing, and Preliminary Evaluating Anti-Bacterial Effects of Derivatives of Serotonin Contain Imidazolidine Ring . (2022). Al Mustansiriyah Journal of Pharmaceutical Sciences, 22(3), 1-16. https://doi.org/10.32947/ajps.v22i3.884

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