Effect of modification of formulation variables on physical characterization of superporouse hydrogel
DOI:
https://doi.org/10.32947/ajps.v23i3.1046Keywords:
Monomer, Cross-linker, Superporous hydrogel (SPH), foaming agent and composite agent. Acryl amide (AM), Trifluoperazine HCl (TRFP), Poly vinyl alcohol (PVA), Super porous hydrogel composite (SPHC), Methylene-Bis-Acrylamide (MBA).Abstract
Superporouse hydrogel (SPH) is widely used and investigated as a gastro retentive drug delivery system to extend drug residence time in the stomach
However, their mechanical strength represents a problem because they need to withstand the peristaltic movement of the stomach. Properties of SPH are widely affected by the materials used for their synthesis. The aim of the research is to study the effect of changing the foaming agent and foam stabilizer amount on physical properties, in particular mechanical strength, and drug release from SPH. Trifluoperazine HCl will be used as model drug in the study.
SPH formulations was prepared using fixed amount of acrylamide (AM) and polyvinyl alcohol (PVA) as monomers, polyethylene glycol diacrylate (PEGDA) as cross-linker, TRFP as model drug and variable amount of sodium bicarbonate (NaHCO3) as foaming agent, and tween 20 as foam stabilizer. Ammonium persulphate (APS) / tetramethyl ethylenediamine (TEMED) system was used as polymerization initiator. The effect of changing foaming agent and foam stabilizer on mechanical strength, buoyancy, porosity, density, drug release, drug content, swelling ratio, and swelling time was investigated.
Modifying both factors affected all the physical properties and drug release profile. When tween 20 was increased the mechanical strength, density and floating lag time was increased with a reduction in porosity and drug release. While increasing NaHCO3 reduced mechanical strength, density and floating lag time with increased porosity and faster drug release was observed. Optimum physical properties were observed in formula 2 which had 230 µl of Tween 20 (v/v) and 50 mg of NaHCO3 in which the mechanical strength was 579±0.4, floating lag time 14 min and 80% of the drug was released within 12 hr.
As a conclusion SPH with improved mechanical strength, physical properties and drug release pattern can be achieved by changing foam stabilizer and foaming agent amount in the formulations.
References
- Kaddoori ZS, Basim M, Mohamed M. ـ Organogel investigations as a floating oral system with depot property. Al Mustansiriyah J Pharm Sci. 2020;20(4).
- Ramu B, S.C.Bose K, Satish Kumar P. Floating drug delivery systems a review. J Chem Pharm Sci. 2011;4(1):39–43.
- Sadiq AAK, Altaii RAJ, Tawfiq FA. Floating Drug Delivery Systems Using Metronidazole as a Model Drug Part I: By Effervescent Method. Al Mustansiriyah J Pharm Sci [Internet]. 2013 Dec 1 [cited 2023 Mar 15];13(2):36–47. Available from: https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/199 DOI: https://doi.org/10.32947/ajps.v13i2.199
- Jonathan TC, Madan SP, Patrick HD, Musa A. Formulation and evaluation of gastro-retentive floating tablets of griseofulvin. African J Pharm Pharmacol. 2022;16(6):90–102. DOI: https://doi.org/10.5897/AJPP2022.5293
- Varshney HM. Research Article A Conceptual Overview on Superporous Hydrogels. Int J Pharm Sci Rev Res. 2014;25(2):166–73.
- Bagadiya A, Kapadiya M MK. Superporous hydrogel : A promising tool for gastoretentive drug delivery system Available Online through. Int J Pharm Technol. 2011;3(4):1556–71.
- Dhingra GA, Goyal S, Sharma S. Synthesis and Characterization of Site Specific Superporous Hydrogel Hybrids of Loratadine. Int J Pharm Sci Res [Internet]. 2017;8(1):151–64. Available from: www.ijpsr.com
- Jeleel HE, Jawad FJ. Formulation and In-vitro Evaluation of Super Porous Hydrogel Composite of Baclofen. Int J Drug Deliv Technol. 2021;11(4):1372–8.
- Jihad HM, Al- Akkam EJ. Formulation and in-vitro Evaluation of Carvedilol Gastroretentive Capsule as (Superporous Hydrogel). Iraqi J Pharm Sci. 2021;30(2):196–207. DOI: https://doi.org/10.31351/vol30iss2pp196-207
- Farag MM, Louis MM, Badawy AA, Nessem DI, Elmalak NSA. Drotaverine Hydrochloride Superporous Hydrogel Hybrid System: a Gastroretentive Approach for Sustained Drug Delivery and Enhanced Viscoelasticity. AAPS PharmSciTech [Internet]. 2022;23(5). Available from: https://doi.org/10.1208/s12249-022-02280-2 DOI: https://doi.org/10.1208/s12249-022-02280-2
- Sharma PK, Asthana GS, Asthana A. Hydrogel advancement: A new approach for gastroretentive drug delivery. Int J Pharm Clin Res. 2016;8(10):1418–22.
- Raghu Kiran CVS, Gopinath C. Development and evaluation of interpenetrating polymer network based superporous hydrogel gastroretentive drug delivery systems (SPH IPN-GRDDS). Mater Today Proc [Internet]. 2020;46(xxxx):3056–61. Available from: https://doi.org/10.1016/j.matpr.2021.02.381 DOI: https://doi.org/10.1016/j.matpr.2021.02.381
- Mircioiu C, Voicu V, Anuta V, Tudose A, Celia C, Paolino D, et al. Mathematical modeling of release kinetics from supramolecular drug delivery systems. Pharmaceutics. 2019;11(3). DOI: https://doi.org/10.3390/pharmaceutics11030140
- Yella S, Rao AS, Kalakonda S. Development and Evaluation of Superporous Hydrogel Tablets of Cefditoren Pivoxil as a Gastroretentive System. 2015;01(03):166–77.
- Zahra Q, Minhas MU, Khan S, Wu PC, Suhail M, Iqbal R, et al. Fabrication of polyethylene glycol hydrogels with enhanced swelling; loading capacity and release kinetics. Polym Bull [Internet]. 2022 Jun 7 [cited 2022 Aug 9];79(7):5389–415. Available from: https://sci-hub.se/https://link.springer.com/article/10.1007/s00289-021-03740-8 DOI: https://doi.org/10.1007/s00289-021-03740-8
- Refai H, Osman D, Khalifa M, Elsalhy S. Trifluoperazine-Loaded Leciplexes as Potential Nasal Delivery Systems for treatment of depression. Azhar Int J Pharm Med Sci. 2022;2(2):70–82. DOI: https://doi.org/10.21608/aijpms.2022.117220.1108
- Pereira ICS, dos Santos NRR, Middea A, Prudencio ER, Luchese RH, Moreira APD, et al. In vitro evaluation of PVA gels loaded with Copaiba Oil and Duotrill®. Polimeros. 2019;29(3):1–8. DOI: https://doi.org/10.1590/0104-1428.03719
- Dakhil IA, Mohamed MBM, Abbas AK, Mansour SM. Formulation and evaluation of trifluoperazine hcl as rectal suppositories by using different types of surfactants in cocoa butter. Res J Pharm Technol. 2019;12(10):4934–40. DOI: https://doi.org/10.5958/0974-360X.2019.00856.4
- Muir VG, Burdick JA. Chemically Modified Biopolymers for the Formation of Biomedical Hydrogels. Chem Rev. 2021;121(18):10908–49. DOI: https://doi.org/10.1021/acs.chemrev.0c00923
- Prasanna Kumar Desu 1 PVR* 2 and VK. SYNTHESIS AND CHARACTERIZATION OF PVA BASED POLY ( ACRYLIC ACID- CO-ACRYLAMIDE ) SUPER POROUS HYDROGELS COMPOSITES. Int J Pharm Sci Res. 2018;9(January 2019):4361–7.
- Adnan SG and N. Effect of Foaming Agent on the Properties of Superporous Hydrogels Prepared via Solution Polymerization Method. Indian J Sci Technol. 2017;10(1):1–6.
- Chavda H V., Patel CN. A newer formulation approach: Superporous hydrogel composite-based bioadhesive drug-delivery system. Asian J Pharm Sci. 2010;5(6):239–50.
- Djemaa I Ben, Auguste S, Drenckhan-Andreatta W, Andrieux S. Hydrogel foams from liquid foam templates: Properties and optimisation. Adv Colloid Interface Sci. 2021;294. DOI: https://doi.org/10.1016/j.cis.2021.102478
- Ghazali S. Effect of Foaming Agent on the Properties of Superporous Hydrogels Prepared via Solution Polymerization Method. Indian J Sci Technol. 2017;10(1):1–6. DOI: https://doi.org/10.17485/ijst/2017/v10i6/111214
- El-said IA, Aboelwafa AA, Khalil RM, Elgazayerly ON. Baclofen novel gastroretentive extended release gellan gum superporous hydrogel hybrid system : in vitro and in vivo evaluation. 2014;7544:1–12. DOI: https://doi.org/10.3109/10717544.2014.905654
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