Autism Spectrum Disorders and Alzheimer's Disease
DOI:
https://doi.org/10.32947/ajps.v25i3.1173Keywords:
Autism, Alzheimer’s disease, NeurologyAbstract
Autism and Alzheimer's disease are neurological disorders associated with defects in certain areas of the brain which share common clinical signs like language impairment, executive function, physiological and pathological abnormalities, DNA methylation, myelin change, and abnormal Peripheral blood cells like B-cell and T-cells.
A genetic factor was proposed as the main cause of disease; however, the molecular mechanisms are still not well known. S-nitrosylation (SNO) in neuropathology targets key protein of gene mutations in patients that may lead to synaptic defects which return to the pathogenesis of Autism and Alzheimer's Disease, while phosphorylation of protein tau and the amyloid-β protein precursor (APP) has been showed to play vital role in neurodevelopmental disorder.
Additionally, neurite growth plays a role in brain enlargement during the first years of human life, typically expanding the anterior cortex of the brain. White matter in the brain and cerebellum appeared in more than half of the human brain that decreased with age, it was determined by a secret of myelin, tumor growth factor, cytokine, and release of kinase enzyme. in contrast, the gray matter was determined by ventricle region, area of cortex, neural stem cell, and thickness. Neurological disorders of mRNA may be due to limited social communication, and irregular behaviors in patients with autism and Alzheimer's disease. Despite that, scientists' efforts to identify management against the progression of this pathology, have only able to decrease some symptoms of autism and Alzheimer's disease are usually available, it’s important to need for additional therapeutic strategies for complications, so, the World Health Organization (WHO) has made this disease a public health priority. The time period specified for this review article lasted from 2013 to 2023.
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