Evaluation of the Possible Protective Effect of Pentoxifylline Against Carbamazepine-Induced Hepatotoxicity in Rat Model
DOI:
https://doi.org/10.32947/ajps.v25i4.1216Keywords:
Carbamazepine, Hepatotoxicity, Pentoxifylline, Alkaline phosphatase, BilirubinAbstract
Hepatotoxicity is considered a primary cause of mortality induced by anticonvulsant medicines such as carbamazepine, which produce inflammation and oxidative stress in the liver; this impact is mitigated by Pentoxifylline, which has an anti-inflammatory and antioxidant action.
This study aims to assess Pentoxifylline's protective effect on liver function enzymes and its possible role in minimizing structural changes and cellular death in hepatocytes during Carbamazepine-induced liver injury in a rat model. Forty rats were randomly assigned to five groups. Each group contained eight rats. Group 1 (Control): rats were given 10ml of distilled water per kg body weight. Group 2 (induction): rats administered Carbamazepine 50 mg/kg body weight. In the other groups, rats were given Pentoxifylline 100 mg/kg of body weight, 200 mg/kg of body weight, and 300 mg/kg of body weight one hour before being given Carbamazepine 50 mg/kg of body weight. Orally for 28 days. A serum was obtained to measure alkaline phosphatase and Bilirubin, and small portions of liver tissue were removed and preserved in 10% buffered formalin, which was then used for histological examination. The results demonstrate a significant (P<0.001) reduction in alkaline phosphatase and Bilirubin with Pentoxifylline groups. The findings revealed that Pentoxifylline protects hepatocytes from Carbamazepine-induced liver damage by improving liver function enzymes and decreasing histological alterations in hepatocytes.
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Copyright (c) 2025 Farah Rafie Mohammed, Yassir Mustafa Kamal, Muthana Ibrahim Hameed, Rawia Abdel-Hadi Elsayed Zayed
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