Assessing the Quality of Life and Survival of Iraqi Patients with Metastatic Colorectal Cancer Receiving Bevacizumab   and Chemotherapy

Rasha M. Faris; Mohammed M. Mohammed; Ayman A. Rafea

doi:10.32947/ajps.v25i4.1218

Authors

Rasha M. Faris College of Pharmacy, Mustansiriyah University, Clinical Pharmacy department, Baghdad / Iraq
Mohammed M. Mohammed College of Pharmacy, Mustansiriyah University, Clinical Pharmacy department, Baghdad / Iraq
Ayman A. Rafea Anbar Specialized Center for Oncology, Department of health Anbar, Anbar / Iraq

DOI:

https://doi.org/10.32947/ajps.v25i4.1218

Keywords:

quality of life, metastatic colorectal cancer, EORTC QLQ-C30, bevacizumab, Global- health status

Abstract

Background: The second most common reason for mortality from cancer is colorectal carcinoma. One of cancer patients' increasingly significant outcome measures is their health-related quality of life.

Objective This cross-sectional study in Iraq aims to examine Quality of life for Iraqi patients who had advanced colorectal cancer (CRC and receiving (chemotherapy + bevacizumab) in addition to find the correlation between Quality-of-life QOL scores and patients’ survival

Methods All patients diagnosed with metastatic colorectal cancer and received bevacizumab in association with chemotherapy from three hospitals in Iraq took involved in this study: Oncology teaching hospital Baghdad Iraq, AL-Anbar center for oncology and AL-Fallujah hospital. All patients were questioned by the researcher from September 2022 to November 2023. The Arabic version Quality-of-Life Questionnaire (QLQ-C30) from the (European Organization for Research and Treatment of Cancer) was utilized for assessment.

Result The global health score of 107 QOL patients with metastatic colorectal cancer is low with a mean 56.54± 5.14. Regarding the Functional scales the Emotional functioning EF was the lowest score of 33.10±27.89. On the other hand, the generic symptoms, financial difficulties and appetite loss were the worst symptom, followed by fatigue. At the same time, there were significant statistical association between several QOL scores and the progression -free -survival (PFS) and the overall- survival (OS).

Conclusion Evaluating the QOL of patients with mCRC is crucial to recognize and managing symptoms associated with the disease as well as treatment by developing a comprehensive care plan and making improvements to their quality of life, as there is a substantial correlation between lower QoL and shorter survival.

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