Synthesis A New Bis Oxazine and Thiazine Derivatives and Study Their Biological Activities

Dina Saleem M. Ameen

doi:10.32947/ajps.v22i4.962

Authors

Dina Saleem M. Ameen College of Pharmacy, AL-Mustansiriyah University, Baghdad, Iraq

DOI:

https://doi.org/10.32947/ajps.v22i4.962

Keywords:

Oxazine, Thiazine, Anticancer, Biological activity

Abstract

Oxazine and thiazine are heterocyclic organic compounds that have a wide range of pharmacological applications. In this study, some chalcone derivatives (1–5) were synthesized based on the reaction of an equal amount of p-substituted acetophenone and terephthalaldehyde in a basic medium. Oxazine derivatives (6-10) and thiazine derivatives (11–15) are synthesized from the reactions of chalcones (1-5) with urea and thiourea, respectively, in a basic medium. The newly synthesized compounds were identified using various physical techniques like 1H-NMR and FT-IR spectra, in addition to docking analysis for some of these derivatives. Finally, these compounds were tested for their biological activity, IC50, and % of PC3 cell line viability as markers of anticancer activity.

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