The Effect of Ring Size on the Biological Activity of Nitrogen Containing Compounds

Authors

  • Sowdani K.M. Department of Pharmaceutical Chemistry and Pharmaconosy, College of PharmacyUniversity of AL-Mustansiriyrah

DOI:

https://doi.org/10.32947/ajps.v12i2.253

Keywords:

Detritiation, Partition Coefficient, TLC, DMSO

Abstract

The biological activity of N-containing ring compounds was studied as a function of the distribution coefficient of these compounds in 1-octanol/water
system. The reaction used to monitor activity is the detritiation of 3[H]- acetophenone in dimethylsulfoxide affected by the nitrogen bases understudy at
25.0oC A strong correlation was found between the rate of detretiation of labeled acetophenone and the basicity of N-containing ring cyclic compounds. The
correlation coefficient and regression constant were 1.0321 and R2= 0.9415 respectively. This finding shows that similar factors were involved in both cases.
Whenever these bases are part of the structure of a drug e.g., they may cause deprotonation of some alkyl groups e.g an acyl hence altering its distribution and
binding to the receptor.

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Published

2012-12-01

How to Cite

K.M., S. (2012). The Effect of Ring Size on the Biological Activity of Nitrogen Containing Compounds. Al Mustansiriyah Journal of Pharmaceutical Sciences, 12(2), 75–81. https://doi.org/10.32947/ajps.v12i2.253