Bis-Schiff Bases of Isatin Derivatives Synthesis, and their Biological Activities: A Review


  • May Mohammed Jawad Al-Mudhafar *Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad Bab Al-Moadham
  • Tagreed N-A Omar *Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad Bab Al-Moadham
  • Shayma L. Abdulhadi *Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad Bab Al-Moadham



: Isatin, Isatin Bis-Schiff bases, biological activities.


Isatin is a heterocyclic molecule that belongs to one of the most important classes of organic compounds known as indolines. Isatin, isatin analogs, and their Schiff bases have recently attracted a lot of attention in medicinal chemistry. Isatin, itself, shows various biological activities such as antiviral, anticancer, antimicrobial, anti-inflammatory, analgesic, antioxidant, and anticonvulsant. Bis- Schiff bases containing isatin moiety have been known to possess a wide spectrum of pharmacological activities. This review offers up-to-date information on the most active isatin bis-Schiff bases, which would include anticancer, antimicrobial, antiviral, anticonvulsant, anti-inflammatory, and analgesic activities. These observations can lead to new molecular modifications that result in compounds with more desirable pharmacological properties


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