Evaluation of Prothrombin Time,International Normalized Ratio, and Activated Partial Thromboplastin Time in Hepatitis B Virus Patients, Sudan2020 -2021

GadAllah Modawe; Esra Awad Mohamed; Ozaz Yagoup Mohamed; AbdelrahmanEldaw Mohammed; Hiba Awadelkareem Osman Fadl; Abdelrahman Hamza Abdelmoneim

doi:10.32947/ajps.v24i1.977

Authors

GadAllah Modawe Department of Biochemistry, Faculty of Medicine and Health Sciences, Omdurman Islamic University, Omdurman, Sudan
Esra Awad Mohamed Faculty of Medical Laboratory Sciences, University of Gezira, WadMedani, Sudan
Ozaz Yagoup Mohamed Faculty of Medical Laboratory Sciences, University of Gezira, WadMedani, Sudan
AbdelrahmanEldaw Mohammed Faculty of Medical Laboratory Sciences, University of Gezira, WadMedani, Sudan
Hiba Awadelkareem Osman Fadl Department of Haematology, Faculty of Medical Laboratory Sciences, Al-Neelain University
Abdelrahman Hamza Abdelmoneim Faculty of Medicine, Al-Neelain University, Khartoum, Sudan

DOI:

https://doi.org/10.32947/ajps.v24i1.977

Keywords:

Hepatitis, PT, APTT, Coagulation profile, Sudan, INR

Abstract

Background: Hepatitis B virus is a growing problem worldwide leading to increasing incidences of life-threatening complications of which liver diseases play a major part of it.

Materials and Methods: To evaluate these effects in Sudanese patients, a cross-sectional study was carried out in Wad Medani teaching hospital from October 2020 to February 2021 for assessing the effect of the disease on the coagulation profile. Patients were randomly selected according to inclusion and exclusion criteria. 2.5ml of blood samples were collected from each patient in tri-sodium citrate containers, and then semi-automated Coatron M4 was used to estimate Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) after calibrated and controlled setting according to the manufacturer’s instructions. SPSS (version 25) was used to analysed data.

Results: A total of 100 hepatitis B virus patients were included in the study, with males representing (79%) and females were (21%), their age were between 18 to 60 years. The study results showed PT prolonged in (98%) of the study population and only (2%) were normal. regarding the APTT (99%) of them had prolonged results (more than the upper normal), and the remaining (1%) was normal. Also, the study results showed there were slight statistically insignificant differences in coagulation profile in hepatitis B virus patients according to gender, age group, family history, and duration of the disease.

Conclusion: hepatitis B infection had a great effect on Coagulation profiles. Therefore, it is recommended on the basis of these results to request PT, INR, and APTT as routine works up for hepatitis B virus patients.

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