1,3,4-OXADIAZOLE: Synthesis Derivatives &Biological Activities. A Review article

Tagreed N-A Omar; May Mohammed Jawad Al-Mudhafar; Azhar Mahdi Jasim; Shayma L. Abdulhadi

doi:10.32947/ajps.v25i5.1294

Authors

Tagreed N-A Omar Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad. Iraq
May Mohammed Jawad Al-Mudhafar Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad. Iraq
Azhar Mahdi Jasim Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad. Iraq
Shayma L. Abdulhadi Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad. Iraq

DOI:

https://doi.org/10.32947/ajps.v25i5.1294

Keywords:

1,3,4-Oxadiazoles synthesis , 1,3,4-oxadiazole derivatives, pharmacological activities heteroaromatic ring

Abstract

Heterocyclic compounds serve as crucial structural elements in the field of pharmaceutical medicinal chemistry. The five-membered heterocyclic nucleus of 1,3,4-oxadiazole occupies a distinctive position within medicinal chemistry and plays a vital role in the development of anticancer agents.

Recognized as a significant pharmacophore for approximately 85 years, 1,3,4-oxadiazole is in high demand across various biological and chemical disciplines. This small and straightforward nucleus is found in numerous compounds that are the focus of research concerning their properties, synthesis, derivatives, and pharmacological activities, including anticancer, antibacterial, antimalarial, anti-inflammatory, antidepressant, analgesic, and antiviral effects. The information regarding these activities presented in this article may prove beneficial to researchers, facilitating the discovery of new therapeutic agents for the benefit of society.

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