Cytotoxicity of Cryptochlorogenic acid against Breast cancer cell line (MCF7) isolated from Moringa oleifera Leaves Cultivated in Iraq

Banan Kareem Bedewi; Ghaith Ali Jasim; Ibrahim Saleh Abbas; BasmaTalib Al-Sudani

doi:10.32947/ajps.v22i2.837

Authors

Banan Kareem Bedewi Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, Mustansiriya University, Baghdad, Iraq.
Ghaith Ali Jasim Department of Pharmacology and Toxicology, College of Pharmacy, Mustansiriya University, Baghdad, Iraq
Ibrahim Saleh Abbas Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, Mustansiriya University, Baghdad, Iraq
BasmaTalib Al-Sudani Department of Pharmacology and Toxicology, College of Pharmacy, Mustansiriya University, Baghdad, Iraq

DOI:

https://doi.org/10.32947/ajps.v22i2.837

Keywords:

Moringa oleifera, Cryptochlorogenic acid, cytotoxicity against (MCF7)

Abstract

oleifera L., a Moringaceae family is fast-growing tree. M. oleifera's dried leaves are Characterized with high in phenolic compounds. phenolic compounds have anti-cancer, anti-microbial, anti-inflammatory, anti-allergic and antioxidant activities.

Therefore, The current study involved isolation Cryptochlorogenic acid by preparative TLC from M.oleifera leaves grown in Iraq, and study its cytotoxicity effect against a breast cancer cell line (MCF7) using the MTT cell viability assay, and comparing it to a standard anticancer drug (Tamoxifen). The isolated Cryptochlorogenic acid was cytotoxic to the MCF7 cell line, with an IC50 of 20.8M.

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