Cytotoxicity of Cryptochlorogenic acid against Breast cancer cell line (MCF7) isolated from Moringa oleifera Leaves Cultivated in Iraq

Authors

  • Banan Kareem Bedewi Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, Mustansiriya University, Baghdad, Iraq.
  • Ghaith Ali Jasim Department of Pharmacology and Toxicology, College of Pharmacy, Mustansiriya University, Baghdad, Iraq
  • Ibrahim Saleh Abbas Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, Mustansiriya University, Baghdad, Iraq
  • BasmaTalib Al-Sudani Department of Pharmacology and Toxicology, College of Pharmacy, Mustansiriya University, Baghdad, Iraq

DOI:

https://doi.org/10.32947/ajps.v22i2.837

Keywords:

Moringa oleifera, Cryptochlorogenic acid, cytotoxicity against (MCF7)

Abstract

  1. oleifera L., a Moringaceae family is fast-growing tree. M. oleifera's dried leaves are Characterized with high in phenolic compounds. phenolic compounds have anti-cancer, anti-microbial, anti-inflammatory, anti-allergic and antioxidant activities.

Therefore, The current study involved isolation Cryptochlorogenic acid by preparative TLC from M.oleifera leaves grown in Iraq,  and study its cytotoxicity effect against a breast cancer cell line (MCF7) using the MTT cell viability assay, and comparing it to a standard anticancer drug (Tamoxifen). The isolated Cryptochlorogenic acid was cytotoxic to the MCF7 cell line, with an IC50 of 20.8M.

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Published

2022-07-05