Recent Trends in Chronopharmaceutics, Pulsatile Drug Delivery System
Pulsatile Drug Delivery Systems (PDDS) are getting considerable interest in delivering a drug at the correct position, at the correct time, and in the correct quantity, thus offering temporal, spatial, and intelligent delivery with improving patient compliance. These systems are
intended to meet body's biological rhythm. Here, the delivery of drugs is assisted by the rhythm of disease. The main reason for the using pulsatile drug release is when the continuous drug release is not required. A PDDS must be designed in such a way that after the lag time a complete and fast release of drugs is achieved. The article deals with various systems such as osmotic system, capsular system, single and multi-unit system based on the utilization of erodible or soluble polymer coating and using of rupturable membrane. These systems are favorable to drugs with chronopharmacological behaviors such as drugs used to treat rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. The current review paper focus on the causes for pulsatile drug delivery system design, types of illness requiring pulsatile release, classification, benefits, and restriction of this drug delivery system.