Review on Gastroretentive Drug Delivery Systems with Emphasis on Film Type
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Abstract
Gastroretentive drug delivery systems (GRDDSs) are highly promising methods for the enhancement of the bioavailability and therapeutic effectiveness of some orally administered medications. The present review focused on gastroretentive film drug delivery methods, specifically developed to extend the duration of medication presence in the stomach which is most likely to enhance their absorption and efficacy.
The review examines different types of gastroretentive films, such as floating, mucoadhesive, and expandable films, emphasizing their respective modes of action, benefits, and drawbacks. Furthermore, the review includes an evaluation of gastroretentive films, which include in vitro buoyancy, swelling index, tensile strength, and drug release kinetics. The prospective clinical uses of these systems in the management of gastrointestinal problems and other medical conditions are also investigated. Lastly, the paper examines the difficulties and potential opportunities for the advancement and commercialization of gastro-retentive film drug delivery systems.
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