Review on Gastroretentive Drug Delivery Systems with Emphasis on Film Type
DOI:
https://doi.org/10.32947/ajps.v25i5.1280Keywords:
Expandable, film, gastroretentive, mucoadhesiveAbstract
Gastroretentive drug delivery systems (GRDDSs) are highly promising methods for the enhancement of the bioavailability and therapeutic effectiveness of some orally administered medications. The present review focused on gastroretentive film drug delivery methods, specifically developed to extend the duration of medication presence in the stomach which is most likely to enhance their absorption and efficacy.
The review examines different types of gastroretentive films, such as floating, mucoadhesive, and expandable films, emphasizing their respective modes of action, benefits, and drawbacks. Furthermore, the review includes an evaluation of gastroretentive films, which include in vitro buoyancy, swelling index, tensile strength, and drug release kinetics. The prospective clinical uses of these systems in the management of gastrointestinal problems and other medical conditions are also investigated. Lastly, the paper examines the difficulties and potential opportunities for the advancement and commercialization of gastro-retentive film drug delivery systems.
References
1- Elsherbeeny walaa, El-Gogary R, Nasr M, Sammour O. Current progress of oral site-specific dosage forms: emphasis on gastroretentive drug delivery systems. Arch Pharm Sci Ain Shams Univ. 2022;6(2):221–38.
2- Lou J, Duan H, Qin Q, Teng Z, Gan F, Zhou X, et al. Advances in oral drug delivery systems: challenges and opportunities. Pharmaceutics. 2023;15(2):1–22.
3- Pund AU, Shendge RS, Pote AK. Current approaches on gastroretentive drug delivery systems. J Drug Deliv Ther. 2020;10(1):139–46.
4- A review on gastroretentive drug delivery system. Int Res J Mod Eng Technol Sci. 2022;4(11):1825–34.
5- Tripathi J, Thapa P, Maharjan R, Jeong SH. Current state and future perspectives on gastroretentive drug delivery systems. Pharmaceutics. 2019;11(4):1–22.
6- Landge P, Lavande J, Swami A, Dharashive V. A review on gastroretentive drug delivery system. Res J Pharm Dos Forms Technol. 2023;(11):62–8.
7- Mahadevan V. Anatomy of the stomach. Surgery. 2014;32(11):571–4.
8- Szarka LA, Camilleri M. Methods for measurement of gastric motility. Am J Physiol - Gastrointest Liver Physiol. 2009;296(3):G461–75.
9- Choudhary S, Waghmare S KHA. Review: gastro retentive drug delivery system. World Gen Pharm Res. 2022;11(2):254–72.
10- Innovations R, Drug ING retentive, Prospect ITS, The IN. RECENT innovations in gastro-retentive drug. World J Pharm Res. 2023;12(17):134–57.
11- Upadhyay P, Deshpande J, Valera AR, Chauhan NP. REVIEW gastroretentive drug delivery systems and recent approaches : a review. J Pharm Res Opin. 2012;1:1–8.
12- Singh S, Chaturvedi S, Agrawal V. Approaches to increase the gastric residence time : floating drug delivery systems- a review approaches to increase the gastric residence time : floating drug delivery systems- a review. Asian J Pharm Clin Res. 2013;6(3):1–9.
13- Gurnany E, Singhai P, Soni A, Jain R, Jain SK, Jain A. Gastro retentive drug delivery system- a review. J Pharm Res. 2011;4(6):1899–908.
14- ML A. Formulation and evaluation of gastroretentive drug delivery system of repaglinide. BR Nahata Smriti Sansthan Int J Phramaceutical Sci Clin Res. 2021;1(2):162–220.
15- Ahmad S, Singh V, Kumar Kushwaha S. Gastro retentive drug delivery system: a review. Asian J Res Chem. 2023;16(6):453–8.
16- Ibrahim M, Naguib YW, Sarhan HA, Abdelkader H. Gastro-retentive oral drug delivery systems : a promising approach for narrow absorption window drugs. J Adv Biomed Pharm Sci. 2019;2:98–110.
17- Khalid Z, Islam S, Jahan MR. Glimpse of comprehensive review on floating drug delivery system ’: a international journal of chemistry and glimpse of comprehensive review on floating drug delivery system : a global perception. Int J Chem Chem Pharm Sci. 2015;2(1):581–96.
18- Sadhu PK, Baji AA, Shah N V., Seth AK, Dash DK, Aundhia CJ, et al. An approaches and patents on controlled release gastroretentive drug delivery system – a review. Int J Pharm Res. 2020;12(2):2047–59.
19- Article R. An overview of the gastroretentive drug delivery system. Int J Pharm Sci. 2023;80(16):104–15.
20- Vinod Kumar, Sushma Somkuwar, Akhlesh Kumar Singhai. A recent update on gastro retentive drug delivery systems. GSC Biol Pharm Sci. 2024;27(1):125–44.
21- Perspectives THEF, On NA, State WC. THE future perspectives and novel approach on gastro retentive drug delivery system (grdds) with currrent state. J Popul Ther Clin Pharmacol. 2023;30:594–613.
22- Shah K, Sharma PK, Bhandari A, Garud A. FLOATING microspheres as gastroretentive drug delivery systems : a review. World J Pharm Res. 2015;4(3):668–84.
23- Swarbrick J, Hill C, Carolina N. Controlled drug delivery. 1987.
24- Sharma D, Sharma SK, Jaimini M, Kumar A. International journal of pharmaceutical, chemical and biological sciences a review on multiparticulate floating drug delivery system. Ijpcbs. 2014;2014(1):201–7.
25- Devkar S. World journal of pharmaceutical research formulation. World J Pharm Res Formul. 2024;13(15):204–22.
26- Print I, Online I, Prajapati KA, Raval AG, Patel YK, Agraval HG. World journal of pharmaceutical sciences geriatric patient. World J Pharm Sci. 2018;6(11):71–83.
27- Development D, Pharmacy I, Ttme GR. Siles research institute, laboratorios almirall s.a. (08024) barcelona (spain). DRUG Dev Ind Pharm. 1994;20(7):1199–212.
28- Gupta R, Tripathi P, Bhardwaj P, Mahor A. Recent advances in gastro retentive drug delivery systems and its application on treatment of h. pylori infections. J Anal Pharm Res. 2018;7(4):404–10.
29- Raut SS. IN-situ raft forming system: a review s. s. raut * and h. a. shinde ngspm’s college of pharmacy, anjaneri, nashik - 422213, maharashtra, india. Int J Pharmacogn. 2018;5(6):337–49.
30- Gopal SV, Chaurasia PK, Pardhe HA, Santosh SS, Sonar NS. Gastroretentive drug delivery system: a systematic review. Asian J Pharm Technol. 2020;10(4):278–84.
31- J BHANDWALKAR M, S DUBAL P, K.TUPE A, N MANDRUPKAR S. Review on gastroretentive drug delivery system. Asian J Pharm Clin Res. 2020;13(12):38–45.
32- Vinchurkar K, Sainy J, Khan MA, Mane S, Mishra DK, Dixit P. Features and facts of a gastroretentive drug delivery system-a review. Turkish J Pharm Sci. 2022;19(4):476–87.
33- Vrettos NN, Roberts CJ, Zhu Z. Gastroretentive technologies in tandem with controlled-release strategies: a potent answer to oral drug bioavailability and patient compliance implications. Pharmaceutics. 2021;13(10):1591.
34- Nayak A. K., Malakar J., Sen K. K. Gastroretentive_drug_delivery_technologi (2). J Pharm Educ Res Vol 1, Issue No 2, December 2010. 2010;1(2):1–12.
35- Morya N, Verma K. Formulation development , optimization and in vitro evaluation of gas based gastroretentive drug delivery system of anti diabetic drug formulation development , optimization and in vitro evaluation of gas based gastroretentive drug delivery system of anti. J Diabetes Metab. 2022;13(May):1–4.
36- Prajapati VD, Jani GK, Khutliwala TA, Zala BS. Raft forming system - an upcoming approach of gastroretentive drug delivery system. J Control Release. 2013;168(2):151–65.
37- Bunlung S, Nualnoi T, Issarachot O, Wiwattanapatapee R. Development of raft-forming liquid and chewable tablet formulations incorporating quercetin solid dispersions for treatment of gastric ulcers. Saudi Pharm J. 2021;29(10):1143–54.
38- Shah S, Hanif M, Abbas G, Rasul A, Zaman M, Rehman A ur, et al. Prompt drug delivery of rabeprazole through raft formation: in vitro and in vivo evaluation. J Drug Deliv Sci Technol. 2020;60(July):101932.
39- Uddin ABMH, Khalid RS, Khan UA, Abbas SA. Journal of applied pharmacy jap. J Appl Pharm. 2013;5(2):748–56.
40- Dangre P, Gundre N, Meshram S, Madia D, Godbole M. Design of dual principles floating osmotic drug delivery system of pioglitazone hydrochloride for gastro ‑ retention : in vitro ‑ in vivo evaluation. J Pharm Innov. 2023;18:2131–44.
41- Shariat Razavi F, Kouchak M, Feizoleslam F, Veysi M. An overview on floating drug delivery systems (fdds); conventional and new approaches for preparation and in vitro -in vivo evaluation. Fabad J Pharm Sci. 2021;46(3):345–62.
42- Kim S, Hwang KM, Park YS, Nguyen TT, Park ES. Preparation and evaluation of non-effervescent gastroretentive tablets containing pregabalin for once-daily administration and dose proportional pharmacokinetics. Int J Pharm. 2018;550(1–2):160–9.
43- Safa Mohammed Nser, Athmar Dhahir Habeeb Al-Shohani. Effect of modification of formulation variables on physical characterization of superporouse hydrogel. Al Mustansiriyah J Pharm Sci. 2023;23(3):285–96.
44- Chavda H, Patel C. Chitosan superporous hydrogel composite-based floating drug delivery system: a newer formulation approach. J Pharm Bioallied Sci. 2010;2(2):124.
45- Safa Mohammed Nser, Athmar Dhahir Habeeb Al-Shohani, Alaa Abuawad. Effect of using high molecular weight crosslinker on the physical properties of super porous hydrogel composite. Al Mustansiriyah J Pharm Sci. 2023;23(4):355–66.
46- Mohan Kumar A, Saravanakumar K, Nagaveni P, Vivek Kumar P, Ramesh B, Gowri Y. A review on floating drug delivery systems. Int J Res Pharm Sci. 2023;5(3):193–9.
47- Sowmya B, Arvapalli S, Gupta AVSSS. World journal of pharmaceutical a review on gastroretentive drug delivery system. World J Pharm Life Sci World J Pharm Life Sci WJPLS. 2019;5(4):101–10.
48- Ponnaganti H, Alluri R, Vemuri J. Formulation and evaluation of gastroretentive floating microspheres of rilpivirine hydrochloride. Int J Pharm Investig. 2021;11(4):403–7.
49- Sharma G, Nautiyal U, Ahmad S. An overview on gastroretentive drug delivery system (grdds). Int J Heal Biol Sci. 2019;2(2):1–8.
50- Bangun H, Arianto A, Rehngenana E. Anti-ulcer effect of gastroretentive drug delivery system of alginate beads containing turmeric extract solid dispersion. Open Access Maced J Med Sci. 2021;9(A):19–27.
51- Soni H. Gastro retentive drug delivery system. Int J Pharm Sci Rev Res. 2011;1(1):01–13.
52- Sharma A, Goyal AK, Rath G. Development and characterization of gastroretentive high- density pellets lodged with zero valent iron nanoparticles. J Pharm Sci. 2018;:1–11.
53- A. Jadhav O, K. Surawase. R, Purkar. Y, Bhadane. S, Shelar S. Gastro-retentive drug delivery system: a comprehensive review and future perspectives. Res J Pharm Dos Forms Technol. 2024;16(3):293–8.
54- Farhadnejad H, Mortazavi SA, Jamshidfar S, Rakhshani A, Motasadizadeh H, Fatahi Y, et al. Montmorillonite-famotidine/chitosan bio-nanocomposite hydrogels as a mucoadhesive/gastroretentive drug delivery system. Iran J Pharm Res. 2022;21(1):1–15.
55- Garg R, Gupta G. Progress in controlled gastroretentive delivery systems. Trop J Pharm Res. 2008;7(3):1055–66.
56- Jadhav RP, Kumbhar SB, Kengar MD. Design and in-vitro evaluation expandable gastro retentive tablets of diltiazem hydrochloride. Asian J Pharm Technol. 2020;10(2):53.
57- Adibkia K, Ghanbarzadeh S, Mohammadi G, Atashgah RB, Sabzevari A. Gastro retentive drug delivery systems: a review. J Reports Pharm Sci. 2010;3(2):02–10.
58- Ito R, Machida Y, Sannan T, Nagai T. Magnetic granules: a novel system for specific drug delivery to esophageal mucosa in oral administration. Int J Pharm. 1990;61(1–2):109–17.
59- Streubel A, Siepmann J, Bodmeier R. Gastroretentive drug delivery systems. Expert Opin Drug Deliv. 2006;3(2):217–33.
60- Cui M, Pan H, Su Y, Fang D, Qiao S, Ding P, et al. Opportunities and challenges of three-dimensional printing technology in pharmaceutical formulation development. Acta Pharm Sin B. 2021;11(8):2488–504.
61- Başarır NS, Mesut B, Özsoy Y. A review on current perspective of gastroretentive drug delivery systems prioritising floating dosage forms güncel bakış açısı ile yüzen dozaj formlarına öncelik vererek gastroretentif i̇laç salım sistemlerinin derlemesi. 2021;
62- Gunjan GG. Gastro retentive floating drug delivery system: an overveiw. Res J Pharm Dos Forms Technol. 2020;12(3):213.
63- Mehta MHR, Patel PgmVK, Assistant. THESIS issn : 2349-2678 “ formulation development and evaluation of gastroretentive floating films of lafutidine .” Int J Pharm Biol Sci Arch. 2019;7(2):16–56.
64- Rhushikesh S, Suresh S. A review on mucoadhesive delivery system. Int J Res Anal Rev. 2020;7(1):793–808.
65- Darandale SS, Vavia PR. Design of a gastroretentive mucoadhesive dosage form of furosemide for controlled release. Acta Pharm Sin B. 2012;2(5):509–17.
66- Safaa Hamdi D, Basim Mohsin Mohamed M. Formulation of metoclopramide hcl gastroretentive film and in vitro- in silico prediction using gastroplus® pbpk software. Saudi Pharm J. 2022;30(12):1816–24.
67- Uboldi M, Pasini C, Pandini S, Baldi F, Briatico-Vangosa F, Inverardi N, et al. Expandable drug delivery systems based on shape memory polymers: impact of film coating on mechanical properties and release and recovery performance. Pharmaceutics. 2022;14(12):1–23.
68- Turac IR, Porfire A, Iurian S, Crișan AG, Casian T, Iovanov R, et al. Expanding the manufacturing approaches for gastroretentive drug delivery systems with 3d printing technology. Pharmaceutics. 2024;16(6):790.
69- Boontawee R, Issarachot O, Kaewkroek K, Wiwattanapatapee R. Foldable/expandable gastro-retentive films based on starch and chitosan as a carrier for prolonged release of resveratrol. Curr Pharm Biotechnol. 2022;23(7):1009–18.
70- Porwal A, Dwivedi H, Pathak K. Gastroretentive bilayer film for sustained release of atorvastatin calcium and immediate release of amlodipine besylate: pharmaceutical, pharmacokinetic evaluation, and ivivc. Vol. 25, Pharmaceutical Development and Technology. Taylor & Francis; 2020. 416–431 p.
71- Verdier N, Foran G, Lepage D, Prébé A, Aymé-Perrot D, Dollé M. Challenges in solvent-free methods for manufacturing electrodes and electrolytes for lithium-based batteries. Polymers (Basel). 2021;13(3):1–26.
72- Prakoso FAH, Indiarto R, Utama GL. Edible film casting techniques and materials and their utilization for meat-based product packaging. Polymers (Basel). 2023;15(13):1–17.
73- Shipp L, Liu F, Kerai-Varsani L, Okwuosa TC. Buccal films: a review of therapeutic opportunities, formulations & relevant evaluation approaches. J Control Release. 2022;352(November):1071–92.
74- Bandari S, Nyavanandi D, Dumpa N, Repka MA. Coupling hot melt extrusion and fused deposition modeling: critical properties for successful performance. Adv Drug Deliv Rev. 2021;172:52–63.
75- Bhagurkar AM, Darji M, Lakhani P, Thipsay P, Bandari S, Repka MA. Effects of formulation composition on the characteristics of mucoadhesive films prepared by hot-melt extrusion technology. J Pharm Pharmacol. 2019;71:293–305.
76- An Q, Jiffrin R, Razak SIA, Jamaludin MI, Hamzah ASA, Mazian MA, et al. Nanocellulose-based films and their emerging applications in the field of sustainable packaging. Carbohydr Polym. 2020;14(18):3725.
77- Carou-Senra P, Rodríguez-Pombo L, Awad A, Basit AW, Alvarez-Lorenzo C, Goyanes A. Inkjet printing of pharmaceuticals. Adv Mater. 2024;36(11):1–28.
78- Eleftheriadis GK, Ritzoulis C, Bouropoulos N, Tzetzis D, Andreadis DA, Boetker J, et al. Unidirectional drug release from 3d printed mucoadhesive buccal films using fdm technology: in vitro and ex vivo evaluation. Eur J Pharm Biopharm. 2019;144(September):180–92.
79- Elkasabgy NA, Mahmoud AA, Maged A. 3D printing: an appealing route for customized drug delivery systems. Int J Pharm. 2020;588(July):119732.
80- Salawi A. An insight into preparatory methods and characterization of orodispersible film—a review. Pharmaceuticals. 2022;15(7):1–17.
81- Mady OY, Abulmeaty MMA, Donia AA, Al-Khureif AA, Al-Shoubki AA, Abudawood M, et al. Formulation and bioavailability of novel mucoadhesive buccal films for candesartan cilexetil in rats. Membranes (Basel). 2021;11(9):1–17.
82- Pamlényi K, Kristó K, Jójárt-Laczkovich O, Regdon G. Formulation and optimization of sodium alginate polymer film as a buccal mucoadhesive drug delivery system containing cetirizine dihydrochloride. Pharmaceutics. 2021;13(5).
83- Al-Mogherah AI, Ibrahim MA, Hassan MA. Optimization and evaluation of venlafaxine hydrochloride fast dissolving oral films. Saudi Pharm J. 2020;28(11):1374–82.
84- Saeed AMH, Alaayedi M, Mansoor Al-Jarsha HY. Effect of natural/ synthetic polymers and super disintegrants on the formulation of zafirlukast fast dissolving film. Res J Pharm Technol. 2022;:1567–72.
85- Mahrous G, Shazly G, Zidan D, Abdel Zaher A, El-Mahdy M. Formulation and evaluation of buccoadhesive films of lidocaine hydrochloride. J Adv Biomed Pharm Sci. 2020;3:53–9.
86- Bácskay I, Hosszú Z, Budai I, Ujhelyi Z, Fehér P, Kósa D, et al. Formulation and evaluation of transdermal patches containing bgp-15. Pharmaceutics. 2024;16(1).
87- Hablawi A, Fattah M, Hblawi A. Proceeding of the 5 th international conference , college of pharmacy , formulation variables influencing the development of ketoconazole gastroretentive drug delivery system. Al-Rafidain J Med Sci. 2024;7(1S):15–23.
88- Alves TFR, Rios AC, Pontes K da S, Portella DL, Aranha N, Severino P, et al. Bilayer mucoadhesive buccal film for mucosal ulcers treatment: development, characterization, and single study case. Pharmaceutics. 2020;12(7):1–24.
89- Calvo NL, Tejada G, Svetaz LA, Quiroga AD, Alvarez VA, Lamas MC, et al. Development and optimization of a new tioconazole vaginal mucoadhesive film using an experimental design strategy. physicochemical and biological characterization. J Pharm Biomed Anal. 2021;205:114303.
90- Bhopaye AG, Bobade NN, Mhaskey YK, Tikait A V. RESEARCH in engineering management development and characterization of gastroretentive floating films of vildagliptin for enhanced diabetes management. IJPREMS. 2024;:807–12.
91- Kaewkroek K, Petchsomrit A, Wira Septama A, Wiwattanapatapee R. Development of starch/chitosan expandable films as a gastroretentive carrier for ginger extract-loaded solid dispersion. Saudi Pharm J. 2022;30(2):120–31.
92- Chittam S, Bhosale A. Development and evaluation of floating and expanding gastroretentive film of furosemide. Int J Pharm Investig. 2020;10(2):179–83.
93- Alaithan S, Naveen NR, Goudanavar PS, Bhavani PD, Ramesh B, Koppuravuri NP, et al. Development of novel unfolding film system of itopride hydrochloride using box-behnken design—a gastro retentive approach. Pharmaceuticals. 2022;15(8):1–20.
94- Wani TU, Fazli AA, Raza SN, Khan NA, Sheikh FA. Formulation and pharmacokinetic evaluation of ethyl cellulose/hpmc-based oral expandable sustained release dosage of losartan potassium. AAPS PharmSciTech. 2022;23(5):160.
95- Zhou W, Yu X, Zhang Z, Zou X, Song H, Zheng W. Preparation and evaluation of luteolin-loaded pla-based shape memory gastroretentive drug delivery systems. Int J Pharm. 2024;650:123670.
96- Anothra P, Pradhan D, Naik PK, Ghosh G, Rath G. Development and characterization of 5-fluorouracil nanofibrous film for the treatment of stomach cancer. J Drug Deliv Sci Technol. 2021;61:102219.
97- ACHARYA HA, Patel RP. Development and optimization of gastro-retentive mucoadhesive formulation of hydralazine hcl. Int J Pharm Sci Drug Res. 2022;14(5):550–8.
98- Venkatesh P, Durga srinivasrao M. Formulation and invitro evaluation of prazosin hydrochloride unfolding type gastro retentive film. YMER Digit. 2022;21(07):460–82.
99- Shailaja P, Loknadh G. Formulation and evaluation of gastro retentive mucoadhesive film of ritonavir. Int J Pharm Sci Res. 2022;13(1):464.
100- Ozcelik E, Sagıroglu AA, Ozsoy Y. Developing, optimization and in vitro evaluating of three-layers floating dipyridamole film in hard gelatine capsule. Acta Pharm Sci. 2021;59(2):253–73.
101- Seiwert H, Baldrian-Hussein F, Mittag A, Findeisen RD, Sprenger A. R eview a rticle . Monum Serica. 1994;42(1):521–60.
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