Role of Surface Active Agents in Transferosome for Systemic Drug Delivery

Mohsin Hussein Abdulameer; Nidhal Khazaal Maraie; Zainab H. Mahdi

doi:10.32947/ajps.v25i1.1107

Authors

Mohsin Hussein Abdulameer Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq
Nidhal K. Maraie Department of Pharmaceutics, College of Pharmacy, Al Farahidi University, Baghdad, Iraq
Zainab H. Mahdi Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science Private University, Amman, Jordan

DOI:

https://doi.org/10.32947/ajps.v25i1.1107

Keywords:

lipid based vesicles, surface active agent, surfactant, transferosome

Abstract

The recent utilization of transferosomes (a type of vesicular drug-carrier system) has shown promising results in enhancing the transport of drugs through the skin when administered topically. Phospholipids and surface active agents constitute the primary components of these entities. Surface active agents play a crucial role in enhancing the permeability and flexibility of lipid bilayers.

The present research critically examines previous studies to gain insights into the influence of surface active agents on the characteristics and performance of transferosomes. Specifically, it focuses on the effects of these agents on transferosome size, entrapment efficiency (EE), zeta potential, stability, and transdermal flux. The type of surface active agent generally exerts a notable influence on the size of vesicles, encapsulation efficiency (EE), and zeta potential. This phenomenon could potentially be attributed to variations in the hydrophilic-lipophilic balance (HLB), the hydrophilicity of the surface active agent, and the length of the carbon chain. Therefore, it is imperative to investigate the influence of surface active agent properties in the development of transferosomes. The evaluation of the cytocompatibility of surface active compounds was also incorporated into the study.

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