Role of Surface Active Agents in Transferosome for Systemic Drug Delivery
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The recent utilization of transferosomes (a type of vesicular drug-carrier system) has shown promising results in enhancing the transport of drugs through the skin when administered topically. Phospholipids and surface active agents constitute the primary components of these entities. Surface active agents play a crucial role in enhancing the permeability and flexibility of lipid bilayers.
The present research critically examines previous studies to gain insights into the influence of surface active agents on the characteristics and performance of transferosomes. Specifically, it focuses on the effects of these agents on transferosome size, entrapment efficiency (EE), zeta potential, stability, and transdermal flux. The type of surface active agent generally exerts a notable influence on the size of vesicles, encapsulation efficiency (EE), and zeta potential. This phenomenon could potentially be attributed to variations in the hydrophilic-lipophilic balance (HLB), the hydrophilicity of the surface active agent, and the length of the carbon chain. Therefore, it is imperative to investigate the influence of surface active agent properties in the development of transferosomes. The evaluation of the cytocompatibility of surface active compounds was also incorporated into the study.
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